Title:
光学活性カルボン酸の製造方法
Document Type and Number:
Japanese Patent JP5683273
Kind Code:
B2
Abstract:
It has been demanded to provide a process for industrially producing an intermediate for a compound that exhibits an inhibitory effect on activated blood coagulation factor X and is useful as a preventive and/or therapeutic agent for thrombotic diseases. The present invention provides a process for producing the (R-±-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid, comprising reacting 3-cyclohexene-1-carboxylic acid and (R)-±-phenylethylamine using a mixed solvent of water and acetone or a mixed solvent of water and ethyl acetate as a solvent.
Inventors:
佐藤 耕司
久保田 和夫
久保田 和夫
Application Number:
JP2010542119A
Publication Date:
March 11, 2015
Filing Date:
December 09, 2009
Export Citation:
Assignee:
第一三共株式会社
International Classes:
C07C51/41; C07C51/02; C07C51/09; C07C51/353; C07C51/43; C07C61/22
Domestic Patent References:
| JP2001151724A | 2001-06-05 | |||
| JP2004123596A | 2004-04-22 | |||
| JP2006169158A | 2006-06-29 |
Other References:
JPN6014020091; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ １００（１６）, 1978, Ｐ５１９９-２０３
JPN6014020092; Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ １５, 2004, Ｐ２０５７-２０６０
JPN6014020093; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３２（１３）, 1991, Ｐ１６１３-１６
JPN6014020089; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ３１, 1966, Ｐ２４０-２４３
JPN6014020090; 日本化学会編，光学異性体の分離［季刊 化学総説 Ｎｏ．６］ 第３版, 19960610, Ｐ４５-５４, 株式会社 学会出版センター
JPN6014020092; Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ １５, 2004, Ｐ２０５７-２０６０
JPN6014020093; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３２（１３）, 1991, Ｐ１６１３-１６
JPN6014020089; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ３１, 1966, Ｐ２４０-２４３
JPN6014020090; 日本化学会編，光学異性体の分離［季刊 化学総説 Ｎｏ．６］ 第３版, 19960610, Ｐ４５-５４, 株式会社 学会出版センター
Attorney, Agent or Firm:
Kimiki Ishibashi
Toshiaki Yaguchi
Noriko Kitano
Imamura Maari
Nakamura Yukiko
Toshiyasu Takemoto
Hironori Kodama
Reiko Kinbara
Toshiaki Yaguchi
Noriko Kitano
Imamura Maari
Nakamura Yukiko
Toshiyasu Takemoto
Hironori Kodama
Reiko Kinbara