Title:
光学活性エステルの製造方法及び光学活性カルボン酸の製造方法
Document Type and Number:
Japanese Patent JP5435656
Kind Code:
B2
Abstract:
Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically active ester is produced while producing an optically active carboxylic acid at the same time by reacting a racemic carboxylic acid with a specific alcohol or phenol derivative in the presence of benzoic anhydride or a derivative thereof and a catalyst such as tetramisole or benzotetramisole, thereby selectively esterifying one enantiomer of the racemic carboxylic acid.
Inventors:
Isamu Shiina
Kenya Nakata
Kenya Nakata
Application Number:
JP2010502778A
Publication Date:
March 05, 2014
Filing Date:
March 04, 2009
Export Citation:
Assignee:
Tokyo University of Science
International Classes:
C07C67/08; C07C51/493; C07C57/30; C07C57/40; C07C57/58; C07C59/64; C07C59/68; C07C59/84; C07C69/612; C07C69/734; C07C69/738; C07B57/00; C07B61/00
Foreign References:
| WO2008140074A1 | 2008-11-20 |
Other References:
JPN6009020734; 中田健也 等: '置換安息香酸無水物法を用いた様々なラセミ第２級ベンジルアルコール類の速度論的光学分割' 第９４回有機合成シンポジウム講演要旨集 , 20081030, 第１４-１５頁
JPN6009020732; 中田健也 等: '置換安息香酸無水物を脱水縮合剤とするラセミカルボン酸およびアルコールの速度論的光学分割' 第９３回有機合成シンポジウム講演要旨集 , 20080530, 第１-４頁
JPN6009020730; ＳＨＩＩＮＡ，Ｉ． ｅｔ ａｌ．: 'Ｔｈｅ ｆｉｒｓｔ ａｓｙｍｍｅｔｒｉｃ ｅｓｔｅｒｉｆｉｃａｔｉｏｎ ｏｆ ｆｒｅｅ ｃａｒｂｏｘｙｌｉｃ ａｃｉｄｓ ｗｉｔｈ ｒａｃｅｍｉｃ ａｌｃｏｈｏｌｓ ｕｓｉｎｇ ｂｅｎｚｏｉｃ ａｎｈ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４８, 2007, ｐ．８３１４-８３１７
JPN6009020727; ＢＩＲＭＡＮ，Ｖ．Ｂ． ｅｔ ａｌ．: 'Ｋｉｎｅｔｉｃ Ｒｅｓｏｌｕｔｉｏｎ ｏｆ Ｐｒｏｐａｒｇｙｌｉｃ Ａｌｃｏｈｏｌｓ Ｃａｔａｌｙｚｅｄ ｂｙ Ｂｅｎｚｏｔｅｔｒａｍｉｓｏｌｅ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．８， Ｎｏ．２１, 2006, ｐ．４８５９-４８６１
JPN6009020732; 中田健也 等: '置換安息香酸無水物を脱水縮合剤とするラセミカルボン酸およびアルコールの速度論的光学分割' 第９３回有機合成シンポジウム講演要旨集 , 20080530, 第１-４頁
JPN6009020730; ＳＨＩＩＮＡ，Ｉ． ｅｔ ａｌ．: 'Ｔｈｅ ｆｉｒｓｔ ａｓｙｍｍｅｔｒｉｃ ｅｓｔｅｒｉｆｉｃａｔｉｏｎ ｏｆ ｆｒｅｅ ｃａｒｂｏｘｙｌｉｃ ａｃｉｄｓ ｗｉｔｈ ｒａｃｅｍｉｃ ａｌｃｏｈｏｌｓ ｕｓｉｎｇ ｂｅｎｚｏｉｃ ａｎｈ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４８, 2007, ｐ．８３１４-８３１７
JPN6009020727; ＢＩＲＭＡＮ，Ｖ．Ｂ． ｅｔ ａｌ．: 'Ｋｉｎｅｔｉｃ Ｒｅｓｏｌｕｔｉｏｎ ｏｆ Ｐｒｏｐａｒｇｙｌｉｃ Ａｌｃｏｈｏｌｓ Ｃａｔａｌｙｚｅｄ ｂｙ Ｂｅｎｚｏｔｅｔｒａｍｉｓｏｌｅ' Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．８， Ｎｏ．２１, 2006, ｐ．４８５９-４８６１
Attorney, Agent or Firm:
Masayuki Masabayashi