Title:
エナミンの光学分割を含むピリド[2,1-a]イソキノリン誘導体の製造方法
Document Type and Number:
Japanese Patent JP2010503634
Kind Code:
A
Abstract:
This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2- is the conjugate base of the resolving agent.
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Inventors:
Abrecht, Stephan
Adan, Jean-Michel
Fetes, Alec
Hirtbrandt, stephan
Adan, Jean-Michel
Fetes, Alec
Hirtbrandt, stephan
Application Number:
JP2009527783A
Publication Date:
February 04, 2010
Filing Date:
September 05, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D471/04; C07B57/00
Foreign References:
| WO2003055881A1 | 2003-07-10 | |||
| WO2005000848A1 | 2005-01-06 | |||
| WO2003055881A1 | 2003-07-10 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito