Title:
３，５−ジヨード−Ｏ−［３−ヨードフェニル］−Ｌ−チロシンの硫酸化誘導体の製造方法
Document Type and Number:
Japanese Patent JP5833222
Kind Code:
B2
Abstract:
The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields.The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets.Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
Inventors:
Pierre Lucio Anelli
Maria Argese
Valeria Boy
Livio Cavalieri
Laura Garimberti
Sonia Gazzetto
Luciano Lattua
Federico Maizano
Giovanni Rivolta
Furvia Vera
Maria Argese
Valeria Boy
Livio Cavalieri
Laura Garimberti
Sonia Gazzetto
Luciano Lattua
Federico Maizano
Giovanni Rivolta
Furvia Vera
Application Number:
JP2014503150A
Publication Date:
December 16, 2015
Filing Date:
April 05, 2012
Export Citation:
Assignee:
BRACCO IMAGING S.P.A.
International Classes:
C07C303/24; C07C305/24
Domestic Patent References:
| JP2006508956A | ||||
| JP7157426A | ||||
| JP8225518A |
Foreign References:
| US2970165 |
Other References:
JAN A MOL,SYNTHESIS AND SOME PROPERTIES OF SULFATE ESTERS AND SULFAMATES OF IODOTHYRONINES,ENDOCRINOLOGY,1985年,V117 N1,P1-7
FEIGENBAUM J,SIMPLIFIED METHOD FOR THE PREPARATION OF AROMATIC SULFURIC ACID ESTERS,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,1941年 1月 1日,V63,P3529-3530
FEIGENBAUM J,SIMPLIFIED METHOD FOR THE PREPARATION OF AROMATIC SULFURIC ACID ESTERS,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,1941年 1月 1日,V63,P3529-3530
Attorney, Agent or Firm:
Samejima Mutsumi
Kyousei Tamura
Masahiro Nitta
Nagatoshi Shinagawa
Kure Hidenori
Nobuhiko Akiyama
Kyousei Tamura
Masahiro Nitta
Nagatoshi Shinagawa
Kure Hidenori
Nobuhiko Akiyama