Title:
生分解性及び温度感応性ポリ有機フォスファゼンの製造方法及び用途
Document Type and Number:
Japanese Patent JP2009531471
Kind Code:
A
Abstract:
The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
Inventors:
Song, Soo Chan
Li, Sun-Mi
Kim, Chang-won
Park, Mylan
Li, Sun-Mi
Kim, Chang-won
Park, Mylan
Application Number:
JP2008551170A
Publication Date:
September 03, 2009
Filing Date:
November 03, 2006
Export Citation:
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECNOLOGY
International Classes:
C08G79/02; A61K9/08; A61K35/12; A61K38/00; A61K39/00; A61K45/00; A61K47/34; A61K48/00; A61P35/00; C07F9/24; C08G79/025
Domestic Patent References:
| JPH09110996A | 1997-04-28 | |||
| JP2006089745A | 2006-04-06 | |||
| JP2006117674A | 2006-05-11 | |||
| JP2008530347A | 2008-08-07 | |||
| JP2006525224A | 2006-11-09 | |||
| JP2003514938A | 2003-04-22 |
Foreign References:
| US4965397A | 1990-10-23 | |||
| WO2005010079A1 | 2005-02-03 |
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito
Yuko Hara
Masakazu Ito
Yuko Hara