Title:
無水プロパンホスホン酸の脱水反応によるニトリルおよびイソニトリルの製造法
Document Type and Number:
Japanese Patent JP4890267
Kind Code:
B2
Abstract:
The invention concerns a method for producing: a) nitriles of formula (II) and b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO-NH2), ammonium salts of carboxylic acids (RCOO-NH4+) or carboxylic acids in the presence of ammonia or ammonium salts (RCOOH+NH3, RCOOH+NH4+) or b) formamides (H-CO-NHR) or mixtures of amines with formic acid, with cyclic phosphonic acid anhydrides while eliminating water at a temperature ranging from -30 to +120° C., in which R represents an arbitrarily substituted linear or branched C1-C8 alkyl radical, a C3-C10 cycloalkyl radical, alkenyl radical, alkynyl radical or an aryl radical or heteroaryl radical. As a cyclic phosphonic acid anhydride, a 2,4,6,-substituted 1,3,5,2,4,6 -trioxatriphosphinane-2,4,6-trioxide of formula (I) is advantageously used, in which: x=3, 4 or 5; R', independent of one another, represents open-chain or branched, saturated or unsaturated, straight-chain C1to C16 alkyl radicals or cyclic C3 to C16 alkyl radicals or aryl or heteroaryl.
Inventors:
Andreas, Moit
Stephan, Scheller
Sufen, Neldinger
Stephan, Scheller
Sufen, Neldinger
Application Number:
JP2006549986A
Publication Date:
March 07, 2012
Filing Date:
January 15, 2005
Export Citation:
Assignee:
ARCHIMICA GMBH
International Classes:
C07C253/06; C07B43/08; C07C253/20; C07C253/22; C07C255/03; C07C255/19; C07C255/50; C07C291/10; C07B61/00
Foreign References:
| US2200734 |
Other References:
M. BIANCHI et al.,European Journal of Medicinal Chemistry,1976年,11(2),pp.101-106
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito