Title:
光学活性β―アミノアルコールの製造法
Document Type and Number:
Japanese Patent JP4761769
Kind Code:
B2
Abstract:
A process for easily producing an optically active beta -amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available alpha -substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active alpha -substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active alpha -substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active beta -substituted amino alcohol. The optically active beta -substituted amino alcohol is subjected to hydrogenolysis to produce an optically active beta -amino alcohol or a salt thereof.
More Like This:
Inventors:
Akira Nishiyama
Kishimoto Shigemi
Nagashima Nobuo
Kishimoto Shigemi
Nagashima Nobuo
Application Number:
JP2004511256A
Publication Date:
August 31, 2011
Filing Date:
June 02, 2003
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C07C221/00; C07C45/63; C07C49/84; C07C213/00; C07C215/28; C07C215/30; C07C215/34; C07C217/70; C07C225/16; C07B57/00
Foreign References:
| DE827950C | 1952-01-14 | |||
| DE927690C | 1955-05-16 |
Previous Patent: ガスタービンエンジンの運転中に燃焼器動圧を低下させるための方法及び...
Next Patent: 好ましくは紙またはボール紙でできた材料シートを処理し、任意でその処...
Next Patent: 好ましくは紙またはボール紙でできた材料シートを処理し、任意でその処...