Title:
A manufacturing process of sepia pterin and tetrahydro Lactoyl pterin
Document Type and Number:
Japanese Patent JP6084967
Kind Code:
B2
Abstract:
To provide a method for producing sepiapterin, lactoylpterin or tetrahydrolactoylpterin. Sepiapterin, lactoylpterin and tetrahydrolactoylpterin are produced at high yield through the following reaction scheme.
Inventors:
Hiroshi Yoshino
Taichi recommenda
Yuichi Castle
Shunichi Murata
Murata Shizuaki
Yasuhiro Kuroda
Taichi recommenda
Yuichi Castle
Shunichi Murata
Murata Shizuaki
Yasuhiro Kuroda
Application Number:
JP2014514717A
Publication Date:
February 22, 2017
Filing Date:
May 07, 2013
Export Citation:
Assignee:
Shiratori Pharmaceutical Co., Ltd.
International Classes:
C07D475/04
Domestic Patent References:
| JP61172877A |
Foreign References:
| WO2011132435A1 | ||||
| WO2005049614A2 |
Other References:
FAN,C.L. et al,Partial purification and some properties of biopterin synthase and dihydropterin oxidase from Drosop,Biochemical Genetics,1979年,Vol.17, No.3-4,pp.351-369
LANDGE,S.S. et al,Chemoselective oxidation of 6-hydroxyalkylpteridine and its application to synthesis of 6-acyl-7,8-d,Heterocycles,2007年,Vol.71, No.4,pp.911-918
CHOI,Y.K. et al,Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyosteliu,Biochimica et Biophysica Acta, General Subjects,2006年,Vol.1760, No.6,pp.877-882
SATO,N. et al,Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids,Journal of Heterocyclic Chemistry,1988年,Vol.25, No.6,pp.1737-1740
PFLEIDERER,W.,Pteridines. LXVIII. Transformation of biopterin into sepiapterin and absolute configuration of sep,Chemische Berichte,1979年,Vol.112, No.7,pp.2750-2755
NAIR,M.G. et al,Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-dea,Journal of Medicinal Chemistry,1989年,Vol.32, No.6,pp.1277-1283
Helvetica Chimica Acta,1978年,Vol.61, No.7,pp.2731-2738
LANDGE,S.S. et al,Chemoselective oxidation of 6-hydroxyalkylpteridine and its application to synthesis of 6-acyl-7,8-d,Heterocycles,2007年,Vol.71, No.4,pp.911-918
CHOI,Y.K. et al,Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyosteliu,Biochimica et Biophysica Acta, General Subjects,2006年,Vol.1760, No.6,pp.877-882
SATO,N. et al,Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids,Journal of Heterocyclic Chemistry,1988年,Vol.25, No.6,pp.1737-1740
PFLEIDERER,W.,Pteridines. LXVIII. Transformation of biopterin into sepiapterin and absolute configuration of sep,Chemische Berichte,1979年,Vol.112, No.7,pp.2750-2755
NAIR,M.G. et al,Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-dea,Journal of Medicinal Chemistry,1989年,Vol.32, No.6,pp.1277-1283
Helvetica Chimica Acta,1978年,Vol.61, No.7,pp.2731-2738
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
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