Title:
A medical treatment agent of sharp pain
Document Type and Number:
Japanese Patent JP6105838
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new therapeutic agent which maintains an effect and can reduce multiple doses with respect to intractable algia such as neuropathic pains compared with the existing nerve block injections of narcotics, antiinflammatory analgesic agents or the like, and to provide a screening method for the new algia therapeutic agent.SOLUTION: It is considered that a brain-derived neurotrophic factor (BDNF) released from sensory nerves (primary neurons) and/or glia cells present in dorsal root ganglia (DRG) by pain stimulation is coupled with a receptor present on the postsynaptic membrane of the posterior horn of spinal cord, the pain signal is transmitted to secondary neurons, and the secondary neurons transmit the signal to brains. The therapeutic agent for algia contains as an active ingredient a substance inhibiting the coupling between the BDNF and its receptor. Further, the screening method for the new algia therapeutic agent screens a substance inhibiting the coupling between the BDNF and its receptor.
Inventors:
Ouchida Mamoru
Itano Gitaro
Hirotaka Kanzaki
Itano Gitaro
Hirotaka Kanzaki
Application Number:
JP2011172529A
Publication Date:
March 29, 2017
Filing Date:
August 08, 2011
Export Citation:
Assignee:
Okayama University
International Classes:
A61K48/00; A61K38/00; A61P25/04; C07K14/705
Domestic Patent References:
| JP9510612A | ||||
| JP2003525253A | ||||
| JP2006517524A |
Foreign References:
| WO2009145067A1 | ||||
| WO2004013157A2 |
Other References:
MANNION,R.J.et al.,Proc.Natl.Acad.Sci.,1999,vol.96,no.16,p.9385-9390
ENDO,T.et al.,Biochemical and Biophysical Research Communications,2009,vol.381,no.3,p.339-3
YAJIMA,Y.et al.,Journal of Neurochemistry,2005,vol.93,no.3,p.584-594
REICHARDT,L.F.et al.,Philos.Trans.R.Soc.B,2006,vol.361,no.1473,p.1545-1564
ENDO,T.et al.,Biochemical and Biophysical Research Communications,2009,vol.381,no.3,p.339-3
YAJIMA,Y.et al.,Journal of Neurochemistry,2005,vol.93,no.3,p.584-594
REICHARDT,L.F.et al.,Philos.Trans.R.Soc.B,2006,vol.361,no.1473,p.1545-1564
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Yuriko Shinobu