Title:
The medical treatment and/or the medicine constituent for prevention of cancer
Document Type and Number:
Japanese Patent JP5906739
Kind Code:
B2
Abstract:
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.
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Inventors:
Shinichi Kobayashi
Fumiyoshi Okano
Takanori Saito
Fumiyoshi Okano
Takanori Saito
Application Number:
JP2011510196A
Publication Date:
April 20, 2016
Filing Date:
February 04, 2011
Export Citation:
Assignee:
TORAY INDUSTRIES,INC.
International Classes:
C07K16/18; A61K38/00; A61K39/395; A61P35/00; A61P35/02; C07K16/46
Foreign References:
| US20050003390A1 | 2005-01-06 | |||
| US20050244413A1 | 2005-11-03 | |||
| US20080075722A1 | 2008-03-27 | |||
| WO2002078524A2 | 2002-10-10 | |||
| WO2002083070A2 | 2002-10-24 | |||
| US20050003390A1 | 2005-01-06 | |||
| US20050244413A1 | 2005-11-03 | |||
| US20080075722A1 | 2008-03-27 |
Other References:
JPN6011010422; ＷＡＮＧ， Ｂ． ｅｔ ａｌ．: 'Ａｂｓｅｎｃｅ ｏｆ Ｃａｐｒｉｎ-１ Ｒｅｓｕｌｔｓ ｉｎ Ｄｅｆｅｃｔｓ ｉｎ Ｃｅｌｌｕｌａｒ Ｐｒｏｌｉｆｅｒａｔｉｏｎ．' Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ， ２００５， Ｖｏｌ．１７５， ｐｐ．４２７４-４２８２
JPN6011010424; ＫＡＤＤＡＲ， Ｔ． ｅｔ ａｌ．: 'Ｔｗｏ ｎｅｗ ｍｉＲ-１６ ｔａｒｇｅｔｓ： ｃａｐｒｉｎ-１ ａｎｄ ＨＭＧＡ１， ｐｒｏｔｅｉｎｓ ｉｍｐｌｉｃａｔｅｄ ｉｎ ｃｅｌｌ ｐｒｏｌｉｆｅｒａｔｉｏｎ．' Ｂｉｏｌｏｇｙ ｏｆ ｔｈｅ Ｃｅｌｌ， ２００９， Ｖｏｌ．１０１， ｐｐ．５１１-５２４
JPN6015016001; 'Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ' ２００４， Ｖｏｌ．１７２， ｐｐ．２３８９-２４００
JPN6011010420; ＫＯＬＯＢＯＶＡ， Ｅ． ｅｔ ａｌ．，: 'Ｍｉｃｒｏｔｕｂｕｌｅ-ｄｅｐｅｎｄｅｎｔ ａｓｓｏｃｉａｔｉｏｎ ｏｆ ＡＫＡＰ３５０Ａ ａｎｄ ＣＣＡＲ１ ｗｉｔｈ ＲＮＡ ｓｔｒｅｓｓ ｇｒａｎｕｌｅｓ．' Ｅｘｐｅｒｉｍｅｎｔａｌ Ｃｅｌｌ Ｒｅｓｅａｒｃｈ， ２００９， Ｖｏｌ．３１５， ｐｐ．５４２-５５５
JPN6011010422; ＷＡＮＧ， Ｂ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ， ２００５， Ｖｏｌ．１７５， ｐｐ．４２７４-４２８２
JPN6011010424; ＫＡＤＤＡＲ， Ｔ． ｅｔ ａｌ．: Ｂｉｏｌｏｇｙ ｏｆ ｔｈｅ Ｃｅｌｌ， ２００９， Ｖｏｌ．１０１， ｐｐ．５１１-５２４
JPN6015016001; 'Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ' ２００４， Ｖｏｌ．１７２， ｐｐ．２３８９-２４００
JPN6011010424; ＫＡＤＤＡＲ， Ｔ． ｅｔ ａｌ．: 'Ｔｗｏ ｎｅｗ ｍｉＲ-１６ ｔａｒｇｅｔｓ： ｃａｐｒｉｎ-１ ａｎｄ ＨＭＧＡ１， ｐｒｏｔｅｉｎｓ ｉｍｐｌｉｃａｔｅｄ ｉｎ ｃｅｌｌ ｐｒｏｌｉｆｅｒａｔｉｏｎ．' Ｂｉｏｌｏｇｙ ｏｆ ｔｈｅ Ｃｅｌｌ， ２００９， Ｖｏｌ．１０１， ｐｐ．５１１-５２４
JPN6015016001; 'Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ' ２００４， Ｖｏｌ．１７２， ｐｐ．２３８９-２４００
JPN6011010420; ＫＯＬＯＢＯＶＡ， Ｅ． ｅｔ ａｌ．，: 'Ｍｉｃｒｏｔｕｂｕｌｅ-ｄｅｐｅｎｄｅｎｔ ａｓｓｏｃｉａｔｉｏｎ ｏｆ ＡＫＡＰ３５０Ａ ａｎｄ ＣＣＡＲ１ ｗｉｔｈ ＲＮＡ ｓｔｒｅｓｓ ｇｒａｎｕｌｅｓ．' Ｅｘｐｅｒｉｍｅｎｔａｌ Ｃｅｌｌ Ｒｅｓｅａｒｃｈ， ２００９， Ｖｏｌ．３１５， ｐｐ．５４２-５５５
JPN6011010422; ＷＡＮＧ， Ｂ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ， ２００５， Ｖｏｌ．１７５， ｐｐ．４２７４-４２８２
JPN6011010424; ＫＡＤＤＡＲ， Ｔ． ｅｔ ａｌ．: Ｂｉｏｌｏｇｙ ｏｆ ｔｈｅ Ｃｅｌｌ， ２００９， Ｖｏｌ．１０１， ｐｐ．５１１-５２４
JPN6015016001; 'Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ' ２００４， Ｖｏｌ．１７２， ｐｐ．２３８９-２４００
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Kosemura Akiko
Satoshi Fujita
Kosemura Akiko
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