Title:
The medical treatment and/or the medicine constituent for prevention of cancer
Document Type and Number:
Japanese Patent JP6065591
Kind Code:
B2
Abstract:
An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
Inventors:
Shinichi Kobayashi
Fumiyoshi Okano
Takanori Saito
Fumiyoshi Okano
Takanori Saito
Application Number:
JP2012543817A
Publication Date:
January 25, 2017
Filing Date:
August 03, 2012
Export Citation:
Assignee:
TORAY INDUSTRIES,INC.
International Classes:
C12N15/09; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07K16/30; C07K19/00
Foreign References:
| WO2010016525A1 | ||||
| WO2010016526A1 | ||||
| WO2010016527A1 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Satoshi Fujita
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