Title:
【発明の名称】タキキニンアンタゴニスト三環式化合物、その製造法並びにそれを含む医薬組成物
Document Type and Number:
Japanese Patent JPH08500331
Kind Code:
A
Abstract:
A description is given of tachykinin antagonist tricyclic compounds having general formula (I) where: X1, X2, X3, X4, X5, and X6, identical or different, are each selected out of the group consisting of -NR'-CO-, -CO-NR'-, where R' is H or C1-3alkyl; Y is selected out of the group consisting of -CONR-, NRCO-, -OCO-, -COO-, -CH2-NR-, -NR-CH2-, -SS-, -CH2-CH2-, cis or trans -CH=CH-, where R is H or C1-3alkyl; R1, R2, R3, and R4 are each a hydrophobic group; n and m, identical or different, are each a whole number from 1 to 4, the preparation of same and pharmaceutical compositions containing said compounds.
Inventors:
Pavone, Vinsenzo
Rombaldi, Angelina
Pedo, carlo
Madge, Carlo Alberto
Kalutara, Laura
Rombaldi, Angelina
Pedo, carlo
Madge, Carlo Alberto
Kalutara, Laura
Application Number:
JP51797493A
Publication Date:
January 16, 1996
Filing Date:
April 13, 1993
Export Citation:
Assignee:
A. Menarini Industrie Pharmachutikiri Unites R.L.
Laboratories Gidotti S.P.A.
Malesi-Istitut Pharmacobiologico S.P.A.
Laboratories Gidotti S.P.A.
Malesi-Istitut Pharmacobiologico S.P.A.
International Classes:
A61K38/00; A61P1/00; A61P9/12; A61P11/00; A61P25/04; A61P25/06; C07D487/08; A61P29/00; A61P35/00; A61P43/00; C07C49/427; C07C49/623; C07D513/08; C07K7/22; C07K7/56; (IPC1-7): C07C49/427; A61K38/00; C07C49/623; C07D487/08; C07D513/08; C07K7/56
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)
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