Title:
PHARMACEUTICAL COMPOSITIONS CONTAINING RAPAMYCIN DERIVATIVES AND PRODUCTION METHOD THEREOF
Document Type and Number:
Japanese Patent JP2017122083
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide pharmaceutical compositions which suppress the reduce of the content of an active ingredient associated with the oxidation or degradation of rapamycin or a derivative thereof, can secure long term stability, and have high safety.SOLUTION: We have found that a pharmaceutical composition prepared by adding a solution containing rapamycin or a derivative thereof into a saccharide with a critical relative humidity at 25°C of 95% or more can suppress the oxidation or degradation of rapamycin or a derivative thereof, and completed the invention. Preferably, as the solution containing the rapamycin or a derivative thereof, a solution containing a stabilizer, such as an antioxidant, and/or a water-soluble polymer carrier, such as a water-soluble cellulose derivative, is used.SELECTED DRAWING: None
Inventors:
KAWAMURA DAI
Application Number:
JP2016248834A
Publication Date:
July 13, 2017
Filing Date:
December 22, 2016
Export Citation:
Assignee:
NIPPON KAYAKU KK
International Classes:
A61K31/436; A61K47/26; A61K47/30; A61K47/38
Domestic Patent References:
| JP2014528431A | 2014-10-27 |
Foreign References:
| WO2015099029A1 | 2015-07-02 |
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