１，３−ジオキソインデン誘導体、その薬学的に許容される塩又は光学異性体、その調製方法及びそれを抗ウイルス活性成分として含有する医薬組成物 - コーリア Research Institute オブ Chemical Technology

Title:

１，３−ジオキソインデン誘導体、その薬学的に許容される塩又は光学異性体、その調製方法及びそれを抗ウイルス活性成分として含有する医薬組成物

Document Type and Number:

Japanese Patent JP2014523416

Kind Code:

A

Abstract:

Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

Inventors:

John John Sik
イチョンキョ
チョイイルヨン
Kim Hye-Soo
Kim ピルホ
Alder スボン
ネイツ Jovan
Thibaud Hendrick Jan

Application Number:

JP2014515763A

Publication Date:

September 11, 2014

Filing Date:

June 18, 2012

Export Citation:

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Assignee:

コーリア Research Institute オブ Chemical Technology
カトリーケ Uni-ヴェルシテイト Roux ヴェン Kay. you. Roux ヴェン R And Dee

International Classes:

C07C69/736; A61K31/122; A61K31/136; A61K31/16; A61K31/166; A61K31/167; A61K31/17; A61K31/215; A61K31/216; A61K31/222; A61K31/435; A61K31/44; A61K31/47; A61K31/655; A61P3/10; A61P9/00; A61P11/02; A61P11/06; A61P17/00; A61P21/00; A61P25/00; A61P27/16; A61P29/00; A61P31/12; A61P31/14; A61P31/16; C07C67/08; C07C67/313; C07C69/16; C07C201/12; C07C205/42; C07C231/02; C07C233/43; C07C233/61; C07C269/04; C07C271/24; C07C273/18; C07C275/26; C07C323/22; C07D213/65; C07D215/20; C07B57/00

Domestic Patent References:

JPS60109541A	1985-06-15
JPS60109541A	1985-06-15

Foreign References:

GB1425295A	1976-02-18
WO2010003023A2	2010-01-07
FR2392951B2	1980-02-08
EP2324820B1	2016-03-02
WO2003082265A
GB1533388A	1978-11-22
FR2392951B2	1980-02-08
EP2324820B1	2016-03-02
WO2003082265A
GB1533388A	1978-11-22
GB1425295A	1976-02-18
WO2010003023A2	2010-01-07

Other References:

JPN6015000458; ＳＯＮＧ，Ｈ．Ｎ．　ｅｔ　ａｌ．: Ｓｙｎｔｈｅｔｉｃ　ＣｏｍｍｕｎｉｃａｔｉｏｎｓＶｏｌ．２９，　Ｎｏ．１６, 1999, ｐ．２７５９-６７
JPN6015000453; ＬＯＭＢＡＲＤＩＮＯ，Ｊ．Ｇ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．１１，　Ｎｏ．６, 1968, ｐ．３４２-７
JPN6015000454; ＴＨＥ　ＭＥＲＣＫ　ＩＮＤＥＸＴｈｉｒｔｅｅｎｔｈ　Ｅｄｉｔｉｏｎ, 2001, ｐ．６７４，１３８０，２４３２，７３１４
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JPN6015000456; ＳＯＮＧ，Ｈ．Ｎ．　ｅｔ　ａｌ．: ＢＵＬＬ．　ＫＯＲＥＡＮ　ＣＨＥＭ．　ＳＯＣ．Ｖｏｌ．２０，　Ｎｏ．１０, 1999, ｐ．１２２９-３１
JPN6015000457; ＤＡＳ，Ｓ．　ｅｔ　ａｌ．: ＴＥＴＲＡＨＥＤＲＯＮ　ＬＥＴＴＥＲＳＶｏｌ．５２, 2011, ｐ．３２４３-６
JPN6015000459; ＤＡＳ，Ｓ．　ｅｔ　ａｌ．: ＳＹＮＬＥＴＴＶｏｌ．２, 2006, ｐ．２０７-１０
JPN6015000458; ＳＯＮＧ，Ｈ．Ｎ．　ｅｔ　ａｌ．: Ｓｙｎｔｈｅｔｉｃ　ＣｏｍｍｕｎｉｃａｔｉｏｎｓＶｏｌ．２９，　Ｎｏ．１６, 1999, ｐ．２７５９-６７
JPN6015000453; ＬＯＭＢＡＲＤＩＮＯ，Ｊ．Ｇ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．１１，　Ｎｏ．６, 1968, ｐ．３４２-７
JPN6015000454; ＴＨＥ　ＭＥＲＣＫ　ＩＮＤＥＸＴｈｉｒｔｅｅｎｔｈ　Ｅｄｉｔｉｏｎ, 2001, ｐ．６７４，１３８０，２４３２，７３１４
JPN6015000455; ＡＬＥＭＡＮ，Ｊ．　ｅｔ　ａｌ．: ＡＮＧＥＷＡＮＤＴＥ　ＣＨＥＭＩＥ　ＩＮＴＥＲＮＡＴＩＯＮＡＬ　ＥＤＩＴＩＯＮＶｏｌ．４６, 2007, ｐ．５５１５-９
JPN6015000456; ＳＯＮＧ，Ｈ．Ｎ．　ｅｔ　ａｌ．: ＢＵＬＬ．　ＫＯＲＥＡＮ　ＣＨＥＭ．　ＳＯＣ．Ｖｏｌ．２０，　Ｎｏ．１０, 1999, ｐ．１２２９-３１
JPN6015000457; ＤＡＳ，Ｓ．　ｅｔ　ａｌ．: ＴＥＴＲＡＨＥＤＲＯＮ　ＬＥＴＴＥＲＳＶｏｌ．５２, 2011, ｐ．３２４３-６
JPN6015000459; ＤＡＳ，Ｓ．　ｅｔ　ａｌ．: ＳＹＮＬＥＴＴＶｏｌ．２, 2006, ｐ．２０７-１０

Attorney, Agent or Firm:

Patent business corporation 3 Edakuni [Hajime] patent firm

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