Title:
A medicine constituent which contains 1, 3* dioxo indene derivative, its salt permitted pharmacologically or an optical isomer, its preparing method, and it as an antiviral activity ingredient
Document Type and Number:
Japanese Patent JP5941142
Kind Code:
B2
Abstract:
Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
Inventors:
John Youngsik
Lee Jung Kyo
Choi Il Young
Kim hess
Kim Pirho
Hans Bonn
Nets Johann
Thibaud Hendrick Yang
Lee Jung Kyo
Choi Il Young
Kim hess
Kim Pirho
Hans Bonn
Nets Johann
Thibaud Hendrick Yang
Application Number:
JP2014515763A
Publication Date:
June 29, 2016
Filing Date:
June 18, 2012
Export Citation:
Assignee:
Corea Research Institute of Chemical Technology
Katrique Universitate Leuven K. You. Leuven Earl and Dee
Katrique Universitate Leuven K. You. Leuven Earl and Dee
International Classes:
C07C69/736; A61K31/122; A61K31/136; A61K31/16; A61K31/166; A61K31/167; A61K31/17; A61K31/215; A61K31/216; A61K31/222; A61K31/435; A61K31/44; A61K31/47; A61K31/655; A61P3/10; A61P9/00; A61P11/02; A61P11/06; A61P17/00; A61P21/00; A61P25/00; A61P27/16; A61P29/00; A61P31/12; A61P31/14; A61P31/16; C07C67/08; C07C67/313; C07C69/16; C07C201/12; C07C205/42; C07C231/02; C07C233/43; C07C233/61; C07C269/04; C07C271/24; C07C273/18; C07C275/26; C07C323/22; C07D213/65; C07D215/20
Domestic Patent References:
| JP60109541A |
Foreign References:
| FR2392951B1 | ||||
| EP2324820B1 | ||||
| WO2003082265A1 | ||||
| GB1533388B | ||||
| GB1425295B | ||||
| WO2010003023A1 |
Other References:
SONG,H.N. et al.,Synthetic Communications,1999年,Vol.29, No.16,p.2759-67
LOMBARDINO,J.G. et al.,Journal of Medicinal Chemistry,1968年,Vol.11, No.6,p.342-7
THE MERCK INDEX,2001年,Thirteenth Edition,p.674,1380,2432,7314
ALEMAN,J. et al.,ANGEWANDTE CHEMIE INTERNATIONAL EDITION,2007年,Vol.46,p.5515-9
SONG,H.N. et al.,BULL. KOREAN CHEM. SOC.,1999年,Vol.20, No.10,p.1229-31
DAS,S. et al.,TETRAHEDRON LETTERS,2011年,Vol.52,p.3243-6
DAS,S. et al.,SYNLETT,2006年,Vol.2,p.207-10
LOMBARDINO,J.G. et al.,Journal of Medicinal Chemistry,1968年,Vol.11, No.6,p.342-7
THE MERCK INDEX,2001年,Thirteenth Edition,p.674,1380,2432,7314
ALEMAN,J. et al.,ANGEWANDTE CHEMIE INTERNATIONAL EDITION,2007年,Vol.46,p.5515-9
SONG,H.N. et al.,BULL. KOREAN CHEM. SOC.,1999年,Vol.20, No.10,p.1229-31
DAS,S. et al.,TETRAHEDRON LETTERS,2011年,Vol.52,p.3243-6
DAS,S. et al.,SYNLETT,2006年,Vol.2,p.207-10
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office