Title:
DRUG LOADED MICROSPHERES FOR POST-OPERATIVE CHRONIC PAIN
Document Type and Number:
Japanese Patent JP2016069378
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a drug loaded microsphere for post-operative chronic pain.SOLUTION: The microsphere includes at least one biodegradable polymer and at least one local anesthetic, where about 75% of the at least one local anesthetic is released by about 72 hours and about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days. In a microsphere, the at least one local anesthetic is bupivacaine, and the at least one biodegradable polymer is poly(lactic-co-glycolic acid).SELECTED DRAWING: None
Inventors:
OHRI RACHIT
GARY R STRICHARTZ
BLASKOVICH PHILLIP
GARY R STRICHARTZ
BLASKOVICH PHILLIP
Application Number:
JP2015188019A
Publication Date:
May 09, 2016
Filing Date:
September 25, 2015
Export Citation:
Assignee:
COVIDIEN LP
International Classes:
A61K9/50; A61K9/107; A61K31/445; A61K47/34; A61P23/02
Domestic Patent References:
| JPH11504634A | 1999-04-27 | |||
| JP2011245293A | 2011-12-08 | |||
| JPH08277216A | 1996-10-22 | |||
| JPH06228011A | 1994-08-16 | |||
| JPH11511763A | 1999-10-12 | |||
| JP2002509107A | 2002-03-26 | |||
| JP2011503213A | 2011-01-27 | |||
| JP2007516747A | 2007-06-28 |
Foreign References:
| EP2614843A2 | 2013-07-17 | |||
| US6217911B1 | 2001-04-17 |
Other References:
REG. ANESTH. PAIN. MED., vol. 37, JPN6019014223, 2012, pages 607 - 615, ISSN: 0004019881
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 107, JPN6019014224, 1994, pages 41 - 49, ISSN: 0004297811
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 107, JPN6019014224, 1994, pages 41 - 49, ISSN: 0004297811
Attorney, Agent or Firm:
Takeshi Oshio