Title:
前立腺癌検出改善のための血清中前立腺特異抗原プロ酵素型の分析方法。
Document Type and Number:
Japanese Patent JP2006508332
Kind Code:
A
Abstract:
Assays for detecting and determining the presence of prostate cancer is provided. The assays are capable of detecting prostate cancer in the population of men with significantly higher ratio of free PSA to total PSA. The assays are also capable of detecting prostate cancer in the population of men with low amount of total PSA, i.e., in the range of 2 to 4 ng/ml. In accordance with one embodiment of the present invention, the assay includes the steps of (a) determining the amount of total PSA contained in a biological sample from the patient, (b) determining the amount of free PSA in the sample; and calculating the ratio of the free PSA to the total PSA, (c) determining the amount of pPSA in the sample, and (d) correlating the amount of pPSA contained in the sample to the presence of prostate cancer in the patient by comparing the amount of pPSA to a predetermined value established with control samples of known cancer and benign disease diagnosis, based on both the level of total PSA and the % free PSA.
Inventors:
Mikola Jakuzic, Steven, Dee
Rittenhouse, Harry, Gee
Rittenhouse, Harry, Gee
Application Number:
JP2004507519A
Publication Date:
March 09, 2006
Filing Date:
May 22, 2003
Export Citation:
Assignee:
Hybridec Incorporated
International Classes:
G01N33/574
Attorney, Agent or Firm:
Nobuyuki Matsunaga
Soichi Kogo
Reitaro Sato
Soichi Kogo
Reitaro Sato