Title:
【発明の名称】新脈管形成抑制のための方法および組成物
Document Type and Number:
Japanese Patent JP2002539076
Kind Code:
A
Abstract:
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple helical forms of the collagen. Antagonists of the invention can target, for example, denatured collagens type-I, type-II, type-III, type-IV, type-V and combinations thereof. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis is normal or diseased tissues both in vivo and ex vivo. Antagonists include monoclonal antibodies referred to as HUI77, HUIV26, and XL313.
Inventors:
Brooks, Peter Sea.
Eric Pettit Clark
Jinson, Eric Shu
Eric Pettit Clark
Jinson, Eric Shu
Application Number:
JP2000592305A
Publication Date:
November 19, 2002
Filing Date:
January 06, 2000
Export Citation:
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA
International Classes:
G01N33/50; A61K31/00; A61K31/337; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K45/06; A61K49/00; A61K51/00; A61P3/10; A61P9/00; A61P9/10; A61P17/02; A61P19/02; A61P19/10; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/06; A61P41/00; A61P43/00; C07K7/06; C07K16/00; C07K16/18; C12P21/08; G01N33/15; G01N33/53; (IPC1-7): A61K45/00; A61K31/7088; A61K38/00; A61K39/395; A61K45/06; A61K49/00; A61K51/00; A61P3/10; A61P9/00; A61P9/10; A61P17/02; A61P19/02; A61P19/10; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/06; A61P41/00; A61P43/00; C07K7/06; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JPH08509294A | 1996-10-01 |
Foreign References:
| EP0921395A2 | 1999-06-09 | |||
| WO1994014070A1 | 1994-06-23 | |||
| US5541295A | 1996-07-30 | |||
| US5320970A | 1994-06-14 | |||
| WO1998035235A1 | 1998-08-13 |
Other References:
JPN7010000759, ＲＡＹ，Ｊ．Ｍ． ｅｔ ａｌ, "Ｔｈｅ ｒｏｌｅ ｏｆ ｍａｔｒｉｘ ｍｅｔａｌｌｏｐｒｏｔｅａｓｅｓ ａｎｄ ｔｈｅｉｒ ｉｎｈｉｂｉｔｏｒｓ ｉｎ ｔｕｍｏｕｒ ｉｎｖａｓｉｏｎ， ｍｅｔａｓｔａｓｉｓ ａｎｄ ａｎｇｉｏｇｅｎ", Ｅｕｒ Ｒｅｓｐｉｒ Ｊ, 1994, Ｖｏｌ．７， Ｎｏ．１１, ｐ．２０６２−７２
JPN7010000760, ＭＩＫＵＮＩ−ＴＡＫＡＧＡＫＩ，Ｙ． ｅｔ ａｌ, "Ｃａｒｔｉｌａｇｅ−ｄｅｇｒａｄｉｎｇ ｎｅｕｔｒａｌ ｐｒｏｔｅｉｎａｓｅ ｓｅｃｒｅｔｅｄ ｂｙ Ｙｏｓｈｉｄａ ｓａｒｃｏｍａ ｃｅｌｌｓ． Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｐｒｏｐｅｒｔｉｅ", Ｊ Ｂｉｏｌ Ｃｈｅｍ, 1984, Ｖｏｌ．２５９， Ｎｏ．１１, ｐ．６７３９−４７
JPN7010000760, ＭＩＫＵＮＩ−ＴＡＫＡＧＡＫＩ，Ｙ． ｅｔ ａｌ, "Ｃａｒｔｉｌａｇｅ−ｄｅｇｒａｄｉｎｇ ｎｅｕｔｒａｌ ｐｒｏｔｅｉｎａｓｅ ｓｅｃｒｅｔｅｄ ｂｙ Ｙｏｓｈｉｄａ ｓａｒｃｏｍａ ｃｅｌｌｓ． Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｐｒｏｐｅｒｔｉｅ", Ｊ Ｂｉｏｌ Ｃｈｅｍ, 1984, Ｖｏｌ．２５９， Ｎｏ．１１, ｐ．６７３９−４７
Attorney, Agent or Firm:
Takashi Ishida (4 others)