Title:
関節リウマチを治療する方法および組成物
Document Type and Number:
Japanese Patent JP2007526230
Kind Code:
A
Abstract:
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin (alpha4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.
More Like This:
Inventors:
Yednock, Theodore, A.
Friedman, Stephen, Bee.
Riverburg, Ivan
Place, Michael, A.
Conrad, Andrey, W.
Shop, george
Messersmith, Elizabeth
Friedman, Stephen, Bee.
Riverburg, Ivan
Place, Michael, A.
Conrad, Andrey, W.
Shop, george
Messersmith, Elizabeth
Application Number:
JP2006517618A
Publication Date:
September 13, 2007
Filing Date:
June 25, 2004
Export Citation:
Assignee:
Elan Pharmaceuticals, Inc.
International Classes:
A61K31/525; A61K31/16; A61K31/18; A61K31/195; A61K31/40; A61K31/415; A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/496; A61K31/506; A61K31/519; A61K31/54; A61K38/00; A61K39/00; A61K39/395; A61P19/02; A61P29/00; C07D213/71; C07D275/06; C07D277/06; C07D279/10; C07D333/46; C07D413/04; C07D417/12; C07C311/19; C07K16/28; C12N15/09; C12P21/08; A61K
Domestic Patent References:
| JP2001512134A | 2001-08-21 | |||
| JP2002535314A | 2002-10-22 | |||
| JP2002512625A | 2002-04-23 | |||
| JP2001512139A | 2001-08-21 | |||
| JP2001512114A | 2001-08-21 |
Attorney, Agent or Firm:
Yasunori Otsuka
Shiro Takayanagi
Yasuhiro Otsuka
Shuji Kimura
Osamu Shimoyama
Shiro Takayanagi
Yasuhiro Otsuka
Shuji Kimura
Osamu Shimoyama