Title:
高コレステロール血症及びアテローム性動脈硬化症を治療するための方法及び組成物
Document Type and Number:
Japanese Patent JP2009530398
Kind Code:
A
Abstract:
The invention provides compounds and pharmaceutical compositions that can be used to treat or prevent atherosclerosis, stroke, and other ischemic vascular diseases, dyslipidemia and hypercholestcrolemia and prevent complications of these conditions. Agents in accordance with the invention include; tauroursodeoxycholic acid (TUDCA), and analogs and derivatives thereof; 4-phenyl butyric acid (PBA), and analogs and derivatives thereof; and trimethyl N-oxide (TMAO), and analogs and derivatives thereof.
Inventors:
Goukhan S Hotami Shrigil
Umut Ozjan
Umut Ozjan
Application Number:
JP2009501575A
Publication Date:
August 27, 2009
Filing Date:
March 22, 2007
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K31/575; A61K31/131; A61K31/192; A61K45/00; A61P3/06; A61P9/10; A61P43/00; C07C57/30; C07C291/04
Domestic Patent References:
| JPS63145232A | 1988-06-17 |
Other References:
JPN6012051257; ＳＯＮＧ，Ｃ． ｅｔ ａｌ: 'Ｓｅｌｅｃｔｉｖｅ ａｃｔｉｖａｔｉｏｎ ｏｆ ｌｉｖｅｒ Ｘ ｒｅｃｅｐｔｏｒ ａｌｐｈａ ｂｙ ６alpha-ｈｙｄｒｏｘｙ ｂｉｌｅ ａｃｉｄｓ ａｎｄ ａｎａｌｏｇｓ' Ｓｔｅｒｏｉｄｓ Ｖｏｌ．６５， Ｎｏ．８, 2000, ｐ．４２３-４２７
Attorney, Agent or Firm:
Norio Saeki