The method and constituent which are related with prevention by RNAi of the gene expression in the mammals - INTERNATIONAL BUSINESS MACHINES CORPORATION

Title:

The method and constituent which are related with prevention by RNAi of the gene expression in the mammals

Document Type and Number:

Japanese Patent JP6247355

Kind Code:

B2

Abstract:

Methods and compositions are provided for modulating, e.g., reducing, coding sequence expression in mammals. In the subject methods, an effective amount of an RNAi agent, e.g., an interfering ribonucleic acid (such as an siRNA or shRNA) or a transcription template thereof, e.g., a DNA encoding an shRNA, is administered to a non-embryonic mammal, e.g., via a hydrodynamic administration protocol. Also provided are RNAi agent pharmaceutical preparations for use in the subject methods. The subject methods and compositions find use in a variety of different applications, including academic and therapeutic applications.

Inventors:

Kai mark
McCaffrey Anton

Application Number:

JP2016159918A

Publication Date:

December 13, 2017

Filing Date:

August 17, 2016

Export Citation:

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Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION

International Classes:

A61K31/713; A01K67/027; A61K9/08; A61K31/70; A61K31/7088; A61K48/00; A61P31/14; A61P43/00; C07H21/02; C12N15/09; C12N15/113; C12N15/85; C12Q1/68

Domestic Patent References:

JP9216825A

Foreign References:

WO2001036646A1
WO2001009159A1
WO2000063364A1
WO1999058694A1
WO1998044953A1

Other References:

Nature,May 2001,Vol.411,p.494-498
Journal of Virology,2001年,Vol.75,p.3469-3473
Nature,2000年,vol. 407,319-320
Nucleic Acids Research,2001年,Vol.29,e55
Genes & Development,Jan.15,2001,Vol.15,p.188-200

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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