Title:
A method for dealing with an antisense antiviral compound and influenza virus infection
Document Type and Number:
Japanese Patent JP5991922
Kind Code:
B2
Abstract:
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. Exemplary antisense antiviral compounds are substantially uncharged, or partially positively charged, morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 30 bases of the 5' or 3' terminus of the positive sense vcRNA; c) the 45 bases surrounding the AUG start codon of an influenza viral mRNA and; d) 50 bases surrounding the splice donor or acceptor sites of influenza mRNAs subject to alternative splicing.
Inventors:
Iblesen, Patrick El.
Application Number:
JP2012539038A
Publication Date:
September 14, 2016
Filing Date:
November 12, 2010
Export Citation:
Assignee:
Saleputa Therapeutics, Incorporated
International Classes:
C12N15/113; A61K31/165; A61K31/43; A61K31/545; A61K31/7056; A61K31/7088; A61K38/08; A61K45/00; A61K48/00; A61P31/04; A61P31/16; A61P43/00
Domestic Patent References:
| JP6501843A |
Foreign References:
| WO2007084359A1 |
Other References:
Journal of General Virology,2008年,vol.89,pp.939-948
Antimicrobial Agents and Chemotherapy,2006年,vol.50,no.11,pp.3724-3733
Molekulyarnaya Biologiya,1991年,25, 5,p.1332-7
Antimicrobial Agents and Chemotherapy,2006年,vol.50,no.11,pp.3724-3733
Molekulyarnaya Biologiya,1991年,25, 5,p.1332-7
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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