Title:
ＳＨＩＰ１モジュレーターおよびそれに関連する方法
Document Type and Number:
Japanese Patent JP6526275
Kind Code:
B2
Abstract:
Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
Inventors:
Lloyd F. Mackenzie
Thomas B. McClury
Curtis harwig
David Bogucky
Jeffrey Earl. Raymond
Jeremy Dee. Pettigrew
Bradymir Krebnikov
Redon shan
Thomas B. McClury
Curtis harwig
David Bogucky
Jeffrey Earl. Raymond
Jeremy Dee. Pettigrew
Bradymir Krebnikov
Redon shan
Application Number:
JP2018042934A
Publication Date:
June 05, 2019
Filing Date:
March 09, 2018
Export Citation:
Assignee:
Aquinox Pharmaceuticals (Canada) Inc.
International Classes:
C07C49/83; A61K31/09; A61K31/12; A61K31/122; A61K31/135; A61K31/145; A61K31/155; A61K31/165; A61K31/166; A61K31/167; A61K31/17; A61K31/18; A61K31/192; A61K31/277; A61K31/40; A61K31/4164; A61K31/417; A61K31/4196; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/443; A61K31/4439; A61K31/444; A61K31/4465; A61K31/455; A61K31/495; A61K31/496; A61K31/4965; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07C43/21; C07C43/23; C07C49/835; C07C49/84; C07C62/38; C07C217/84; C07C225/20; C07C233/31; C07C233/32; C07C233/60; C07C233/76; C07C235/82; C07C237/04; C07C255/47; C07C275/26; C07C275/64; C07C279/16; C07C311/07; C07C311/19; C07C323/22; C07C323/31; C07C335/14; C07D207/335; C07D211/62; C07D213/38; C07D213/50; C07D213/75; C07D213/81; C07D213/82; C07D213/89; C07D233/60; C07D233/64; C07D241/24; C07D249/08; C07D295/112; C07D295/215; C07D307/68; C07D401/12; C07D405/12
Domestic Patent References:
| JP2009541224A | ||||
| JP2006506363A | ||||
| JP2001048873A | ||||
| JP2001031663A | ||||
| JP11349478A |
Foreign References:
| WO1999053911A1 | ||||
| US20110136802 |
Other References:
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Journal of Organic Chemistry,2003年,Vol.68(17),p.6611-6618
Medicinal Research Reviews,2006年,Vol.26(2),p.223-268
Chemistry - A European Journal,2005年,Vol.11(12),p.3659-3667
JOURNAL OF ORGANIC CHEMISTRY,1981年,Vol.46,p.1362-1366
Phytochemistry,1982年,Vol.21(8),p.2021-2025
European Journal of Medicinal Chemistry,2010年,Vol.45(7),p.3155-3161
Journal of the Chemical Society, Perkin Transactions 1,1989年,Vol.(3),p.559-562
Croatica Chemica Acta,1985年,Vol.58(4),p.491-509
Tetrahedron Letters,1964年,Vol.47,p.3475-3480
Heterocycles,1998年,Vol.49,p.315-325
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry,1968年,Vol.24(Pt.6),p.855-865
Journal of the Chemical Society,1955年,p.658-665
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita