Title:
The method and intermediate for producing a JAK depressant
Document Type and Number:
Japanese Patent JP5977354
Kind Code:
B2
Abstract:
This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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Inventors:
Jiachen Chow
Liu Pinri
Khao Gan Feng
Woo Young Jung
Liu Pinri
Khao Gan Feng
Woo Young Jung
Application Number:
JP2014529844A
Publication Date:
August 24, 2016
Filing Date:
September 06, 2012
Export Citation:
Assignee:
INCYTE HOLDINGS CORPORATION
International Classes:
C07F7/12; C07D401/06; C07D487/04; C07D491/113
Domestic Patent References:
| JP5858484B2 | ||||
| JP2013522214A | ||||
| JP2013523884A | ||||
| JP2011514909A | ||||
| JP11513679A | ||||
| JP11508892A |
Other References:
Reductive aminations of carbonyl compounds with borohydride and borane reducing agents,Organic Reactions,2002年,1,P1-57
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists,Bioorg. Med. Chem. Lett,2005年,Vol. 15, No. 5,1375-1378
Protection for the hydroxyl group,Green’s protective groups in organic synthesis,2007年,Fourth edition P54-58
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists,Bioorg. Med. Chem. Lett,2005年,Vol. 15, No. 5,1375-1378
Protection for the hydroxyl group,Green’s protective groups in organic synthesis,2007年,Fourth edition P54-58
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai