Title:
活性メチレン基のジメチル化の方法
Document Type and Number:
Japanese Patent JP2012522746
Kind Code:
A
Abstract:
The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin.
Inventors:
Swing, swing
Thiepal, Anton
Thiepal, Anton
Application Number:
JP2012502628A
Publication Date:
September 27, 2012
Filing Date:
March 30, 2010
Export Citation:
Assignee:
Let's Farmer's Medicals Day Day
International Classes:
C07C253/30; A61K31/165; A61K31/395; A61P9/12; C07C231/12; C07C237/06; C07C255/19; C07D273/08; C07B61/00
Domestic Patent References:
| JPH11263766A | 1999-09-28 | |||
| JP2001502298A | 2001-02-20 |
Foreign References:
| WO2005077948A1 | 2005-08-25 |
Other References:
JPN5012009505; ＨＵＡ ＤＯＮＧ: 'ＰＲＡＣＴＩＣＡＬ ＳＹＮＴＨＥＳＩＳ ＯＦ ＡＮ ＯＲＡＬＬＹ ＡＣＴＩＶＥ ＲＥＮＩＮ ＩＮＨＩＢＩＴＯＲ ＡＬＩＳＫＩＲＥＮ' ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４６ Ｎ３７, 2005, Ｐ６３３７-６３４０
Attorney, Agent or Firm:
Kawaguchi International Patent Office