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Title:
内寄生性生物駆除剤としての18の環原子を有する乳酸含有性環式デプシペプチド類ならびにそれらの製造のための方法
Document Type and Number:
Japanese Patent JP3600300
Kind Code:
B2
Abstract:
Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically active, cyclic depsipeptides with 18 ring atoms (enniatins)of formula (I) from optically active amino acids of formula (II)-(IV), optically active or racemic alpha -hydroxy acids of formula (V) and (VI) and optically active or racemic lactic acid, where the reaction is effected in the presence of a Fusarium fungus in a nutrient medium or in the presence of a microbial synthetase in a buffer system: R1,R2 and R4 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, guanidinoalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2; R3 and R5 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2.

Inventors:
Peter Yesuke
Achim Halder
Norbert Menke
Horst Kleinkauf
Liner tzuohiya
Application Number:
JP5527995A
Publication Date:
December 15, 2004
Filing Date:
February 21, 1995
Export Citation:
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Assignee:
Bayer Aktiengesellschaft
International Classes:
A01N43/72; A61K31/395; A61K38/00; A61K38/15; A61P33/00; A61P33/10; C07C229/12; C07C229/14; C07C235/12; C07C271/22; C07D273/00; C07K11/02; C12P17/14; C12P21/04; (IPC1-7): C07K11/02; A01N43/72; A61K31/395; A61K38/00; A61P33/00; A61P33/10; C07D273/00
Domestic Patent References:
JP7508723A
Other References:
Molecular Microbiology, 7(6), pp905-914, 1993
J. Antibiotics, 45(8), pp1207-1215, 1992
Biochemistry, 21(1), pp43-48, 1982
CAN. J. CHEM., 70, pp1281-1287, 1992
Attorney, Agent or Firm:
Heikichi Odashima