Title:
A method for manufacturing a thieno pyrimidine compound
Document Type and Number:
Japanese Patent JP6123097
Kind Code:
B2
Abstract:
Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
Inventors:
Bab, Shrinivasan
Chen, Degan
France, Goslan
Hidvar, Pirmin
Hoffman, Asara
Humphreys, Teresa
Reinz, Reinhard
Thien, chinpin
Yajima, Herbert
Chen, Degan
France, Goslan
Hidvar, Pirmin
Hoffman, Asara
Humphreys, Teresa
Reinz, Reinhard
Thien, chinpin
Yajima, Herbert
Application Number:
JP2015536109A
Publication Date:
May 10, 2017
Filing Date:
October 09, 2013
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D495/04; C07D295/185
Domestic Patent References:
| JP2010512338A |
Foreign References:
| CN102675323A | ||||
| CN102399235A |
Other References:
MOLANDER, G. A. et al.,Scope of the Palladium-Catalyzed Aryl Borylation Utilizing Bis-Boronic Acid,Journal of the American Chemical Society,2012年 6月 6日,Vol. 134, No. 28,pp. 11667-11673
BRAVO-ALTAMIRANO, K. et al.,Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D,ACS Medicinal Chemistry Letters,2011年,Vol. 2, No. 2,pp. 154-159
BRAVO-ALTAMIRANO, K. et al.,Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D,ACS Medicinal Chemistry Letters,2011年,Vol. 2, No. 2,pp. 154-159
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation