Title:
The method and means for the medical treatment of degenerative arthritis
Document Type and Number:
Japanese Patent JP6200929
Kind Code:
B2
Abstract:
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and /or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and /or cartilage and inflammation.
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Inventors:
Reginald Kuhristophe Quabiel Bruis
Ruuk Neruruesu
Nikku Ernesto Rene Bandeghinste
Bull and rice Mirru Ebaker
Michelle Angelo Tessari
Ruuk Neruruesu
Nikku Ernesto Rene Bandeghinste
Bull and rice Mirru Ebaker
Michelle Angelo Tessari
Application Number:
JP2015216256A
Publication Date:
September 20, 2017
Filing Date:
November 04, 2015
Export Citation:
Assignee:
Galapagos N.V.
International Classes:
G01N33/68; A61K45/00; A61P19/02; A61P29/00; C12Q1/02; C12Q1/68; C40B30/06; G01N33/15; G01N33/50
Domestic Patent References:
| JP2008516593A | ||||
| JP2007537134A | ||||
| JP2003225093A | ||||
| JP2004244339A |
Foreign References:
| WO2006125827A1 | ||||
| WO2007027509A2 |
Other References:
PORTER S,The ADAMTS metalloproteinases,Biochem J,2005年,Vol.386 No.1,Page.15-27
Romeo, Salvatore,The role of noncartilage-specific molecules in differentiation of cartilaginous tumors: lessons from chondroblastoma and chondromyxoid fibroma,Cancer,2007年,Vol.110 No.2,Page.385-394
Nam, Jin,Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis,PLoS One,2011年,Vol.6 No.9,Page.e24320
Gruber HE,Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs,Spine J,2010年 8月,Vol.10 No.8,Page.721-727
Akyol, Sumeyya,Regeneration and healing of bone and cartilage in type-1 and type-2 diabetes: the effects of insulin,Turkish Journal of Biology,2016年,Vol. 40, No. 2,pp. 327-332
Romeo, Salvatore,The role of noncartilage-specific molecules in differentiation of cartilaginous tumors: lessons from chondroblastoma and chondromyxoid fibroma,Cancer,2007年,Vol.110 No.2,Page.385-394
Nam, Jin,Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis,PLoS One,2011年,Vol.6 No.9,Page.e24320
Gruber HE,Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs,Spine J,2010年 8月,Vol.10 No.8,Page.721-727
Akyol, Sumeyya,Regeneration and healing of bone and cartilage in type-1 and type-2 diabetes: the effects of insulin,Turkish Journal of Biology,2016年,Vol. 40, No. 2,pp. 327-332
Attorney, Agent or Firm:
Toru Ishikawa