Title:
METHODS FOR PREDICTING SURVIVAL TIME AND TREATMENT RESPONSIVENESS OF A PATIENT SUFFERING FROM A SOLID TUMOR USING A SIGNATURE OF AT LEAST SEVEN GENES
Document Type and Number:
Japanese Patent JP2019162138
Kind Code:
A
Abstract:
To provide methods and kits for predicting the survival time and responsiveness of a patient suffering from a solid tumor.SOLUTION: The invention is characterized in that the survival time and responsiveness of a patient can be predicted by determining the gene expression levels of at least seven genes selected from the group consisting of CCR2, CD3D, CD3E, CD3G, CD8A, CXCL10, CXCL11, GZMA, GZMB, GZMK, GZMM, IL15, IRF1, PRF1, STAT1, CD69, ICOS, CXCR3, STAT4, CCL2 and TBX21 in a tumor sample obtained from the patient.SELECTED DRAWING: None
Inventors:
JEROME GALON
FRANCK PAGES
BERNHALD MLECNIK
GABRIELA BINDEA
FRANCK PAGES
BERNHALD MLECNIK
GABRIELA BINDEA
Application Number:
JP2019099354A
Publication Date:
September 26, 2019
Filing Date:
May 28, 2019
Export Citation:
Assignee:
INST NATL DE LA SANTE & DE LA RECH MEDICAL
UNIV PARIS DESCARTES
HOPITAUX PARIS ASSIST PUBLIQUE
UNIV PARIS DESCARTES
HOPITAUX PARIS ASSIST PUBLIQUE
International Classes:
C12Q1/6851; C12Q1/686; G01N33/68
Domestic Patent References:
| JP2009515148A | 2009-04-09 | |||
| JP2009538607A | 2009-11-12 | |||
| JP2015528698A | 2015-10-01 |
Foreign References:
| WO2010144192A1 | 2010-12-16 |
Other References:
THE JOURNAL OF IMMUNOLOGY, vol. 180, JPN6017015964, 2008, pages 8184 - 8191, ISSN: 0004298279
JOURNAL OF TRANSLATIONAL MEDICINE, vol. 9, no. 146, JPN6017015966, 2011, ISSN: 0004298280
ONCOGENE, vol. 29, JPN6017015967, 2010, pages 1093 - 1102, ISSN: 0004298281
JOURNAL OF TRANSLATIONAL MEDICINE, vol. 9, no. 146, JPN6017015966, 2011, ISSN: 0004298280
ONCOGENE, vol. 29, JPN6017015967, 2010, pages 1093 - 1102, ISSN: 0004298281
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe