Title:
【発明の名称】閉環ジインメタセシスによる大環状生産物の調製法
Document Type and Number:
Japanese Patent JP2002502832
Kind Code:
A
Abstract:
The present invention relates to methods for preparing macrocyclic products having 9 or more ring atoms by ring-closing diyne metathesis of suitable diyne substrates. The diyne substrates can be converted into cycloalkynes or into cycloalkadiynes by cyclodimerization, depending on the particular reaction conditions. Any alkyne metathesis catalyst can be used as the catalyst, regardless of whether said catalysts are heterogeneously or homogeneously present in the reaction medium. The preferred catalysts or pre-catalysts are transition metal alkylidyne complexes, transition metal compounds which form alkylidyne complexes under the reaction conditions, and transition metal compounds with metal-metal triple bonds. The method can be carried out with numerous functional groups, solvents, and additives. Using known methods, the formed macrocyclic cycloalkynes or cycloalkadiynes can be converted into numerous secondary products, especially macrocyclic cycloalkenes with a uniform configuration of the double bond, and used, e.g., for the synthesis of epothilone or epothilone analogues.
Inventors:
Aloys Furstner
Gunter Seidel
Antonio Lumbo
Christian mates
Gunter Seidel
Antonio Lumbo
Christian mates
Application Number:
JP2000530479A
Publication Date:
January 29, 2002
Filing Date:
February 02, 1999
Export Citation:
Assignee:
Studiengesellschaft Kohle mbH
International Classes:
B01J31/12; C07B37/10; C07B61/00; C07D245/02; C07D313/00; C07D315/00; C07D321/00; C07D323/00; C07D327/10; C07D491/04; C07D491/056; C07F7/08; (IPC1-7): C07B37/10; B01J31/12; C07F7/08
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)