Title:
カルボン酸のニトロオキシアルキル置換エステルの製造法、その方法において有用な中間体およびその製造法
Document Type and Number:
Japanese Patent JP2005536559
Kind Code:
A
Abstract:
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
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Inventors:
Del Soldato, Clown
Giancarlo, Santas
Benedini, Franceska
Giancarlo, Santas
Benedini, Franceska
Application Number:
JP2004532055A
Publication Date:
December 02, 2005
Filing Date:
August 06, 2003
Export Citation:
Assignee:
NICOX S.A.
International Classes:
A61K31/618; A61K31/216; C07B61/00; C07C67/10; C07C69/734; C07C201/02; C07C201/04; C07C201/08; C07C203/00; C07C203/04; C07C269/06; C07C271/28; (IPC1-7): C07C201/04; A61K31/216; A61K31/618; C07C203/00
Domestic Patent References:
| JPH05279359A | 1993-10-26 | |||
| JPH05247015A | 1993-09-24 |
Foreign References:
| WO2000061537A2 | 2000-10-19 |
Attorney, Agent or Firm:
Shintaro Nogawa