Title:
ヘパリンを含有する生体吸収性高分子からなる多孔質基材の製造方法、ヘパリンを含有する生体吸収性高分子からなる多孔質基材、及び、人工血管
Document Type and Number:
Japanese Patent JP6916193
Kind Code:
B2
Abstract:
The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.
Inventors:
Hidetaka Nakayama
Shunji Niioka
Shuhei Tara
Sugiura Yuhisa
Shunji Niioka
Shuhei Tara
Sugiura Yuhisa
Application Number:
JP2018540943A
Publication Date:
August 11, 2021
Filing Date:
August 31, 2017
Export Citation:
Assignee:
GUNZE LIMITED
International Classes:
A61L33/10; A61L27/18; A61L27/50; A61L27/56; A61L27/58
Domestic Patent References:
| JP5184662A | ||||
| JP2011212437A | ||||
| JP2016158765A |
Attorney, Agent or Firm:
Atomi International Patent Office