Title:
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
Document Type and Number:
Japanese Patent JP5173546
Kind Code:
B2
Abstract:
The present invention relates to a method of removing a silyl protecting group from an oligonucleotide, said method comprising the step of admixing the oligonucleotide with particular agents.
Inventors:
Musia Manoharan
Michael e jung
Karan Sotasil Gee Rajeev
Rajendra Panday
Gun one
Michael e jung
Karan Sotasil Gee Rajeev
Rajendra Panday
Gun one
Application Number:
JP2008104337A
Publication Date:
April 03, 2013
Filing Date:
April 14, 2008
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
International Classes:
C07C327/12; C07C327/16; C07C327/18; C07C333/08; C07C333/14; C07D207/327; C07D213/59; C07D213/83; C07D285/00; C07D285/01; C07D339/00; C07D339/04; C07D339/08; C07D495/04; C07D495/14; C07F9/6561; C07H21/00; C07H21/04; C12N15/09
Domestic Patent References:
| JP2000510872A | ||||
| JP2304568A | ||||
| JP2005515261A | ||||
| JP61167945A | ||||
| JP6047275A | ||||
| JP6279634A | ||||
| JP2003064065A | ||||
| JP1283284A | ||||
| JP63281150A | ||||
| JP2002501534A |
Foreign References:
| NL8902521A | ||||
| WO1993013118A1 | ||||
| US3276950 | ||||
| WO1995025753A1 | ||||
| DE2228364A | ||||
| US3753908 | ||||
| US3621030 | ||||
| US3956303 | ||||
| DE2404477A1 | ||||
| EP0992506A1 | ||||
| US5852168 |
Other References:
Nucleic Acids Research,1995年,Vol.23,No.20,p.4029-4033
Journal of Inorganic and Nuclear Chemistry,1981年,Vol.43,No.11,p.2729-2734
RUBBER CHEMISTRY AND TECHNOLOGY,1945年,Vol.18,p.110-115
Heterocycles ,1994年,Vol.38,No.5,p.1015-1024
Chemische Berichte,1981年,Vol.114,No.2,p.549-563
Zeitschrift fuer Chemie,1982年,Vol.22,No.10,p.377
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1979年,Vol.17B,No.1,p.17-19
Journal of Inorganic and Nuclear Chemistry,1981年,Vol.43,No.11,p.2729-2734
RUBBER CHEMISTRY AND TECHNOLOGY,1945年,Vol.18,p.110-115
Heterocycles ,1994年,Vol.38,No.5,p.1015-1024
Chemische Berichte,1981年,Vol.114,No.2,p.549-563
Zeitschrift fuer Chemie,1982年,Vol.22,No.10,p.377
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1979年,Vol.17B,No.1,p.17-19
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma