リジルｔＲＮＡ合成酵素の細胞内水準を調節して癌転移又は癌細胞の移動を調節する方法

Japanese Patent JP5628807

B2

The present invention relates to a novel function of lysyl tRNA synthetase, that is, lysyl tRNA synthetase interacts with 67LR through translocation of KRS into plasma membrane, and so enhances tumor (or cancer) cell migration, thereby having an effect on cancer metastasis. More specifically, it relates to method for controlling cancer metastasis or cancer cell migration by modulating an cellular level of lysyl tRNA synthetase, an use of an expression vector comprising a construct inhibiting KRS expression for preventing or treating cancer, an use of an agent inhibiting KRS activity for preventing or treating cancer, a method for screening an agent which modulates cancer metastasis or cancer cell migration, a method for screening an agent inhibiting an interaction between KRS and 67LR. Accordingly, cancer metastasis and cancer cell migration may be controlled using the inventive KRS, further the cellular metabolism related to laminin receptor (67LR) of plasma membrane may be controlled. The relationship between KRS and laminin receptor disclosed in the present invention may be very useful for treatment, prevention and/or diagnosis of various disease related to thereof.

キム， スンフン
チョイ， ジン ウー

JP2011523721A

November 19, 2014

August 18, 2008

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ソウル ナショナル ユニバーシティー インダストリー ファウンデーション

A61K31/7088; A61K31/7105; A61K31/713; A61K39/395; A61K45/00; A61K48/00; A61P35/04; C07K16/40; C12N15/09; C12N15/11; C12N15/113; C12Q1/02; G01N33/15; G01N33/50; G01N33/566; G01N33/573

Kihei Watanabe
Isao Okano
Yuko Tanaka
Morishima It sees.
Nakayama Shin-ichi
Tetsuya Imai
Raw wealth Seiichi

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