Title:
ＴＷＥＡＫ関連状態を治療するための方法
Document Type and Number:
Japanese Patent JP5603040
Kind Code:
B2
Abstract:
The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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Inventors:
Linda Barkley
アニエラ ジャクボウ skiing
Timothy Senn
キュンミン Harm
アニエラ ジャクボウ skiing
Timothy Senn
キュンミン Harm
Application Number:
JP2009202035A
Publication Date:
October 08, 2014
Filing Date:
September 01, 2009
Export Citation:
Assignee:
Biogen Idec MA, Incorporated
International Classes:
A01K67/027; A61K39/395; A61K38/00; A61K45/00; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P9/00; A61P9/04; A61P11/00; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P19/04; A61P21/00; A61P25/00; A61P43/00; C07K14/28; C07K14/525; C07K14/705; C07K16/24; C07K16/28; C07K19/00; C12N5/071; C12N5/074; C12N15/09; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita