Title:
METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION
Document Type and Number:
Japanese Patent JP2018024698
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for inhibiting the action of MASP-2 dependent complement activation in living subjects, which methods comprises a step of administering a MASP-2 inhibitory agent in an amount effective to inhibit the effects of MASP-2 dependent complement activation to a subject in need thereof.SOLUTION: The MASP-2 inhibitory agent inhibits cellular injury associated with the MASP-2 mediated complement pathway activation, while leaving the classic (C1q-dependent) pathway components of the immune system intact. Also provided is a composition for inhibiting the effects of lectin-dependent complement activation, which comprises a therapeutically effective amount of MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.SELECTED DRAWING: Figure 45
Inventors:
GREGORY A DEMOPULOS
TOM DUDLER
HANS-WILHELM SCHWAEBLE
TOM DUDLER
HANS-WILHELM SCHWAEBLE
Application Number:
JP2017209894A
Publication Date:
February 15, 2018
Filing Date:
October 31, 2017
Export Citation:
Assignee:
UNIV LEICESTER
OMEROS CORP
OMEROS CORP
International Classes:
A61K45/00; A61K39/395; A61K45/06; A61P1/00; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P11/00; A61P13/02; A61P13/12; A61P15/00; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P43/00; C07K16/18
Domestic Patent References:
| JP2009532493A | 2009-09-10 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto