Title:
細胞分離のためのマイクロ流体デバイスおよびその使用
Document Type and Number:
Japanese Patent JP2006501449
Kind Code:
A
Abstract:
The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a mixture of cells is introduced into a microfluidic channel that selectively allows the passage of a desired type of cell, and the population of cells enriched in the desired type is then introduced into a second microfluidic channel that allows the passage of the desired cell to produce a population of cells further enriched in the desired type. The selection of cells is based on a property of the cells in the mixture, for example, size, shape, deformability, surface characteristics (e.g., cell surface receptors or antigens and membrane permeability), or intracellular properties (e.g., expression of a particular enzyme).
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Inventors:
Toner Mumet
Truski George
Kapoor Rabi
Truski George
Kapoor Rabi
Application Number:
JP2004540301A
Publication Date:
January 12, 2006
Filing Date:
September 29, 2003
Export Citation:
Assignee:
THE GENERAL HOSPITALCORPORATION
G.P.B. Scientific LLC
G.P.B. Scientific LLC
International Classes:
G01N33/48; B01L3/00; B01L99/00; B81B1/00; C12M1/26; C12N1/02; C12N5/00; C12N5/02; C12N5/06; G01N33/49; G01N33/53; G01N33/543; G01N33/569; G01N37/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi