Title:
ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
Document Type and Number:
Japanese Patent JP2009536313
Kind Code:
A
Abstract:
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscrible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
Inventors:
Link, Darren Earl.
Boitard, Laurent
Branch Fort, Jeffrey
Charles, Eve
Fake, gilbert
Lou, John Kew.
Malan, David
Tabatabai, Armadari
Weiner, Michael
Hints, Wolfgang
Rossburg, Jonathan M.
Boitard, Laurent
Branch Fort, Jeffrey
Charles, Eve
Fake, gilbert
Lou, John Kew.
Malan, David
Tabatabai, Armadari
Weiner, Michael
Hints, Wolfgang
Rossburg, Jonathan M.
Application Number:
JP2008550290A
Publication Date:
October 08, 2009
Filing Date:
June 01, 2006
Export Citation:
Assignee:
Raindance Technologies, Inc.
International Classes:
G01N35/08; B01J13/00; B01J19/00; B81B1/00; G01N21/64; G01N33/53; G01N33/536; G01N33/566; G01N37/00; G01N21/05; G01N21/27; G01N21/47
Domestic Patent References:
| JP2001194373A | 2001-07-19 | |||
| JP2003222633A | 2003-08-08 | |||
| JP2002282682A | 2002-10-02 | |||
| JP2002085961A | 2002-03-26 | |||
| JP2003502656A | 2003-01-21 |
Foreign References:
| WO2005021151A1 | 2005-03-10 | |||
| WO2004088314A1 | 2004-10-14 |
Other References:
JPN5008023741; ＳＯＮＧ Ｈ．: ＡＮＧＥＷＡＮＤＴＥ ＣＨＥＭＩＥ ＩＮＴ．ＥＤ． Ｖ４２ Ｎ７, 2003, Ｐ７６７-７７２
JPN5008023741; ＳＯＮＧ Ｈ．: ＡＮＧＥＷＡＮＤＴＥ ＣＨＥＭＩＥ ＩＮＴ．ＥＤ． Ｖ４２ Ｎ７, 2003, Ｐ７６７-７７２
JPN5008023741; ＳＯＮＧ Ｈ．: ＡＮＧＥＷＡＮＤＴＥ ＣＨＥＭＩＥ ＩＮＴ．ＥＤ． Ｖ４２ Ｎ７, 2003, Ｐ７６７-７７２
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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