Title:
高い均質性を有する口内分散性錠剤及びその調製方法
Document Type and Number:
Japanese Patent JP2005511589
Kind Code:
A
Abstract:
The invention relates to a rapid-disintegrating tablet of the type which is intended to disintegrate in the mouth on contact with the saliva in less than 40 seconds, preferably in under 30 seconds, and which forms an easy-to-swallow suspension. The inventive tablet is made from at least one active material which takes the form of coated microcrystals or microgranules and a mixture of excipients in the form of grains. The aforementioned mixture of excipients has the following composition: between 60 and 85% of a diluent; between 3 and 20% of a decomposing agent; between 1 and 8% of a sweetening agent; between 0 and 5% of a gliding agent; between 0 and 10% of a binder; and between 0 and 10% of a permeabilising agent, a swelling agent and/or a lubricant. The above-mentioned percentages are weight percentages in relation to the total weight of the grains of the excipients. Said excipient grains have a median particle size of between +30 and -30 %, and preferably between +10 and -10%, in relation to the dimension of the coated microcrystals or microgranules.
More Like This:
| WO/2000/003710 | OXAZOLIDINONES TO TREAT EYE INFECTIONS |
| WO/1993/016690 | CYTOPROTECTIVE COMPOSITIONS CONTAINING PYRUVATE AND ANTIOXIDANTS |
Inventors:
Edouard Gendrow
Nuwar Redin Knowli
Pascal spree
Nuwar Redin Knowli
Pascal spree
Application Number:
JP2003541811A
Publication Date:
April 28, 2005
Filing Date:
October 28, 2002
Export Citation:
Assignee:
Ethi farm
International Classes:
A61K9/00; A61K9/20; A61K9/26; A61K47/04; A61K47/10; A61K47/18; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61P25/18; A61P29/00; A61P31/00; A61P31/12; A61P35/00; (IPC1-7): A61K9/20; A61K47/04; A61K47/10; A61K47/18; A61K47/32; A61K47/34; A61K47/36; A61K47/38
Domestic Patent References:
| JP2001058944A | 2001-03-06 | |||
| JP2000095673A | 2000-04-04 | |||
| JPH1143429A | 1999-02-16 | |||
| JPH06502194A | 1994-03-10 | |||
| JP2000178183A | 2000-06-27 |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Masakazu Aoyama
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Masakazu Aoyama
Yasuhiko Murayama
Shinya Mitsuhiro