Title:
The multiplication inhibition method of a cell, the nucleic acid molecule which has a RNA interference operation on a NEK10 variant gene, and an anticancer agent
Document Type and Number:
Japanese Patent JP6018068
Kind Code:
B2
Abstract:
The present invention provides a method for inhibiting cell growth, a nucleic acid molecule useful as an anticancer agent, and a method for screening novel anticancer agents. In the present invention, inhibitory effects on expression of NEK10 variant gene or inhibitory effects on activity of NEK10 variant protein are obtained in cells by transfecting cells with a nucleic acid molecule having an RNA interference effect on NEK10 variant gene. The present invention also provides a method for screening anticancer agents by using this inhibitory effect as an indicator.
Inventors:
Manabu Sato
Application Number:
JP2013533600A
Publication Date:
November 02, 2016
Filing Date:
August 29, 2012
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
C12N15/09; A61K31/713; A61K48/00; A61P35/00; C12N15/113
Domestic Patent References:
| JP2007282628A | ||||
| JP2004203745A |
Foreign References:
| WO2010094734A1 | ||||
| WO2007117038A1 | ||||
| WO2005061704A1 |
Other References:
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Database GenBank,2006年 9月14日,アクセッション番号AK098832,[検索日2012.09.21],URL,http://www.ncbi.nlm.nih.gov/nuccore/AK098832
Pharmacology & Therapeutics,2006年,vol.111,pp.974-984
GENE,2004年,vol.328,pp.135-142
THE JOURNAL OF BIOLOGICAL CHEMISTRY,2003年,vol.278 no.37,pp.34897-34909
The EMBO Journal,1998年,vol.17 no.2,pp.470-481
Cancer Res,2005年,vol.65 no.17,pp.7591-7595
Cancer Res,2010年,vol.70 no.23,pp.9742-9754
NATURE GENETICS,2009年,vol.41 no.5,pp.585-590
Breast Cancer RESEARCH,2010年,vol.12 R10,pp.1-12
Cancer Genetics and Cytogenetics,2010年,vol.199,pp.69-72
Journal of Reproduction and Development,2011年 3月,vol.57 no.1,pp.107-112
Attorney, Agent or Firm:
Masatake Shiga
Sumio Tanai
Shiro Suzuki
Makiko Otsuki
Sumio Tanai
Shiro Suzuki
Makiko Otsuki
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