Title:
The mutant antibody of an anti-HER2 perfect human antibody, the genes which code it, and those use
Document Type and Number:
Japanese Patent JP6263778
Kind Code:
B2
Abstract:
The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 1 1, SEQ ID NO: 2; or SEQ ID NO:12, SEQ ID NO:2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.
Inventors:
Butterfly, chin
Shu, Yang Jun
Fu, Chutz
Rin, Jun
Shu, Yang Jun
Fu, Chutz
Rin, Jun
Application Number:
JP2016562486A
Publication Date:
January 24, 2018
Filing Date:
December 08, 2015
Export Citation:
Assignee:
Geno Byopharma Company Limited
International Classes:
C12N15/09; A61K39/395; A61P35/00; A61P35/02; C07K16/28
Domestic Patent References:
| JP2011517456A | ||||
| JP2004501605A |
Foreign References:
| US5714350 |
Other References:
Igawa, T. et al.,Engineering the variable region of therapeutic IgG antibodies,mAbs,2011年,Vol. 3,pp. 243-252
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi