神経培養システム - Axogen Corporation

Title:

神経培養システム

Document Type and Number:

Japanese Patent JP7209799

Kind Code:

B2

Abstract:

Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.

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Inventors:

Dyster, cart
Tajdaran, Kasula

Application Number:

JP2021179119A

Publication Date:

January 20, 2023

Filing Date:

November 02, 2021

Export Citation:

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Assignee:

Axogen Corporation

International Classes:

C12Q1/04; G01N33/48; G01N33/50

Domestic Patent References:

JP2005500375A

Other References:

Exp. Neurol.,2010年,Vol. 223,p. 112-118

Attorney, Agent or Firm:

Makoto Onda
Hironobu Onda
Atsushi Honda

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