Title:
新規の抗炎症性アンドロスタン誘導体
Document Type and Number:
Japanese Patent JP4495456
Kind Code:
B2
Abstract:
There are provided compounds of formula (I) wherein R1 represents O, S or NH; R2 represents -C(-O)-aryl or -C(-O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the alpha or beta configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and ![custom character]()
represents a single or a double bond; and salts and solvates thereof; process for preparing them, compositions containing them and their use in therapy.
Inventors:
Bigger dyke, keith
Jones, Paul
Payne, Jeremy, John
Jones, Paul
Payne, Jeremy, John
Application Number:
JP2003538181A
Publication Date:
July 07, 2010
Filing Date:
October 17, 2002
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K9/12; C07J17/00; A61K31/58; A61K31/585; A61P5/44; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P29/00; A61P37/08; C07J31/00; C07J33/00; C07J43/00
Domestic Patent References:
| JP49080058A | ||||
| JP11501675A | ||||
| JP57146800A | ||||
| JP2004501930A | ||||
| JP2004505989A | ||||
| JP2004505990A |
Foreign References:
| US3828080 | ||||
| WO2002066422A1 |
Other References:
ISOGAI M,JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,英国,ELSEVIER SCIENCE LTD,1993年,V44 N2,P141-145
POPPER T L,JOURNAL OF STEROID BIOCHEMISTRY,英国,PERGAMON PRESS PLC,1987年,V27 N4-6,P837-843
SHAPIRO E L,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1987年,V30 N9,P1581-1588
POPPER T L,JOURNAL OF STEROID BIOCHEMISTRY,英国,PERGAMON PRESS PLC,1987年,V27 N4-6,P837-843
SHAPIRO E L,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1987年,V30 N9,P1581-1588
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Yumi Naito
Ishii Teiji
Satoshi Fujita
Yumi Naito