Title:
The new anti-inflammatory metabolite of omega 3 system fatty acid origin
Document Type and Number:
Japanese Patent JP5909183
Kind Code:
B2
Abstract:
The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, d ocosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
Inventors:
Makoto Arita
Hiroyuki Arai
Yousuke Isobe
Kubota Yufumi
Hiroyuki Arai
Yousuke Isobe
Kubota Yufumi
Application Number:
JP2012529482A
Publication Date:
April 26, 2016
Filing Date:
August 04, 2011
Export Citation:
Assignee:
National University Corporation Tokyo University
International Classes:
C07D303/38; A61K31/336; A61P1/04; A61P1/16; A61P5/24; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P15/08; A61P25/00; A61P29/00; A61P35/00; C12P7/42; C12P7/64
Foreign References:
| WO2001060778A2 | 2001-08-23 | |||
| WO2006055965A2 | 2006-05-26 |
Other References:
JPN6015033839; ＫＡＴＯ， Ｔ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｔｈｅ ｅｎａｎｔｉｏｍｅｒｓ ｏｆ １９-ｅｐｏｘｙ ｄｏｃｏｓａｈｅｘａｅｎｏｉｃ ａｃｉｄｓ ａｎｄ ｔｈｅｉｒ ４-ｈｙｄｒｏｘｙ ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ １１（４）, 2000, ｐｐ． ８５１-８６０
JPN6015033842; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｄｅｔｅｒｍｉｎａｔｉｏｎ ｏｆ ｐｏｌｙｕｎｓａｔｕｒｅｄ ｆａｔｔｙ ａｃｉｄ ｍｏｎｏｅｐｏｘｉｄｅｓ ｂｙ ｈｉｇｈ ｐｅｒｆｏｒｍａｎｃｅ ｌｉｑｕｉｄ ｃｈｒｏｍａｔｏｇｒａｐｈｙ-ｍａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１１５（１-２）, 2006, ｐｐ． １-７
JPN6015033833; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｍｅｔａｂｏｌｉｓｍ ｏｆ ｅｉｃｏｓａｐｅｎｔａｅｎｏｉｃ ａｎｄ ｄｏｃｏｓａｈｅｘａｅｎｏｉｃ ａｃｉｄｓ ｂｙ ｒｅｃｏｍｂｉｎａｎｔ ｈｕｍａｎ ｃｙｔｏｃｈｒｏｍｅｓ Ｐ４５０' Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ ４７１（２）, 2008, ｐｐ． １１６-１２５
JPN6015033836; ＡＲＩＴＡ， Ｍ． ｅｔ ａｌ．: 'Ｔｈｅ ｃｏｎｔｒｉｂｕｔｉｏｎｓ ｏｆ ａｓｐｉｒｉｎ ａｎｄ ｍｉｃｒｏｂｉａｌ ｏｘｙｇｅｎａｓｅ ｔｏ ｔｈｅ ｂｉｏｓｙｎｔｈｅｓｉｓ ｏｆ ａｎｔｉ-ｉｎｆｌａｍｍａｔｏｒｙ ｒｅｓｏｌｖ' Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ３３８（１）, 2005, ｐｐ． １４９-１５７
JPN6015033839; ＫＡＴＯ， Ｔ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｔｈｅ ｅｎａｎｔｉｏｍｅｒｓ ｏｆ １９-ｅｐｏｘｙ ｄｏｃｏｓａｈｅｘａｅｎｏｉｃ ａｃｉｄｓ ａｎｄ ｔｈｅｉｒ ４-ｈｙｄｒｏｘｙ ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ １１（４）, 2000, ｐｐ． ８５１-８６０
JPN6015033842; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｄｅｔｅｒｍｉｎａｔｉｏｎ ｏｆ ｐｏｌｙｕｎｓａｔｕｒｅｄ ｆａｔｔｙ ａｃｉｄ ｍｏｎｏｅｐｏｘｉｄｅｓ ｂｙ ｈｉｇｈ ｐｅｒｆｏｒｍａｎｃｅ ｌｉｑｕｉｄ ｃｈｒｏｍａｔｏｇｒａｐｈｙ-ｍａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１１５（１-２）, 2006, ｐｐ． １-７
JPN6015033842; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｄｅｔｅｒｍｉｎａｔｉｏｎ ｏｆ ｐｏｌｙｕｎｓａｔｕｒｅｄ ｆａｔｔｙ ａｃｉｄ ｍｏｎｏｅｐｏｘｉｄｅｓ ｂｙ ｈｉｇｈ ｐｅｒｆｏｒｍａｎｃｅ ｌｉｑｕｉｄ ｃｈｒｏｍａｔｏｇｒａｐｈｙ-ｍａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１１５（１-２）, 2006, ｐｐ． １-７
JPN6015033833; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｍｅｔａｂｏｌｉｓｍ ｏｆ ｅｉｃｏｓａｐｅｎｔａｅｎｏｉｃ ａｎｄ ｄｏｃｏｓａｈｅｘａｅｎｏｉｃ ａｃｉｄｓ ｂｙ ｒｅｃｏｍｂｉｎａｎｔ ｈｕｍａｎ ｃｙｔｏｃｈｒｏｍｅｓ Ｐ４５０' Ａｒｃｈｉｖｅｓ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｐｈｙｓｉｃｓ ４７１（２）, 2008, ｐｐ． １１６-１２５
JPN6015033836; ＡＲＩＴＡ， Ｍ． ｅｔ ａｌ．: 'Ｔｈｅ ｃｏｎｔｒｉｂｕｔｉｏｎｓ ｏｆ ａｓｐｉｒｉｎ ａｎｄ ｍｉｃｒｏｂｉａｌ ｏｘｙｇｅｎａｓｅ ｔｏ ｔｈｅ ｂｉｏｓｙｎｔｈｅｓｉｓ ｏｆ ａｎｔｉ-ｉｎｆｌａｍｍａｔｏｒｙ ｒｅｓｏｌｖ' Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ３３８（１）, 2005, ｐｐ． １４９-１５７
JPN6015033839; ＫＡＴＯ， Ｔ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｔｈｅ ｅｎａｎｔｉｏｍｅｒｓ ｏｆ １９-ｅｐｏｘｙ ｄｏｃｏｓａｈｅｘａｅｎｏｉｃ ａｃｉｄｓ ａｎｄ ｔｈｅｉｒ ４-ｈｙｄｒｏｘｙ ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ １１（４）, 2000, ｐｐ． ８５１-８６０
JPN6015033842; ＦＥＲ， Ｍ． ｅｔ ａｌ．: 'Ｄｅｔｅｒｍｉｎａｔｉｏｎ ｏｆ ｐｏｌｙｕｎｓａｔｕｒｅｄ ｆａｔｔｙ ａｃｉｄ ｍｏｎｏｅｐｏｘｉｄｅｓ ｂｙ ｈｉｇｈ ｐｅｒｆｏｒｍａｎｃｅ ｌｉｑｕｉｄ ｃｈｒｏｍａｔｏｇｒａｐｈｙ-ｍａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１１５（１-２）, 2006, ｐｐ． １-７
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama