Title:
NOVEL BIOMARKERS FOR SUB-TYPING PANCREATIC DUCTAL ADENOCARCINOMA
Document Type and Number:
Japanese Patent JP2018105876
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide novel approaches for identification and stratification of subtypes of pancreatic ductal adenocarcinoma (PDAC).SOLUTION: In vitro method for subtype-specific detection of PDAC cells in a tumor sample is provided, the method being characterized by a step of detecting expression of subtype-specific markers either as proteins or as oligonucleotides encoding such proteins, where keratin 81 is a marker for PDAC cells of the quasi-mesenchymal subtype, and HNF-1A is a marker for cells of the exocrine-like subtype. PDAC cells of the classical subtype are characterized by the absence of keratin 81 and HNF-1A.SELECTED DRAWING: Figure 1
Inventors:
CHRISTIAN THOMAS EISEN
TRUMPP ANDREAS
MARTIN RONALD SPRICK
TRUMPP ANDREAS
MARTIN RONALD SPRICK
Application Number:
JP2018019195A
Publication Date:
July 05, 2018
Filing Date:
February 06, 2018
Export Citation:
Assignee:
HI STEM GGMBH
International Classes:
G01N33/574; C12N15/09; C12Q1/68; G01N33/53; G01N33/536
Domestic Patent References:
| JP2010533836A | 2010-10-28 | |||
| JP2012522217A | 2012-09-20 | |||
| JP2012509683A | 2012-04-26 |
Foreign References:
| US20030180747A1 | 2003-09-25 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki