Title:
【発明の名称】新規の第四級アンモニウム誘導体、その調製方法及びその薬学的使用
Document Type and Number:
Japanese Patent JP2003503407
Kind Code:
A
Abstract:
A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R1, R2 and R3 represent alkyl, or R1, R2 and R3 together with the nitrogen atom carrying them, form a heterocycle, X represents a (C1-C6)alkylene chain in which one or more -CH2- groups are optionally replaced by sulphur, oxygen, or -NR-, -CO-, -CO-NH-, -CO2-, -SO- or -SO2-, n represents 0 or 1, Hal represents halogen, or, R4 represents alkyl, Hal represents halogen, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond.
Inventors:
Madlemont, Jean-Claude
Jiro, Isabel
Nicola Collet
Maurice, Jean-Claude
Rap, Marize
Orie, Monik
Renard, Pierre
Canary, Daniel-Henri
Jiro, Isabel
Nicola Collet
Maurice, Jean-Claude
Rap, Marize
Orie, Monik
Renard, Pierre
Canary, Daniel-Henri
Application Number:
JP2001507029A
Publication Date:
January 28, 2003
Filing Date:
June 22, 2000
Export Citation:
Assignee:
Réra Bora Toir Servier
Ansitu National de la Sant'E de la Cherche Medical
Ansitu National de la Sant'E de la Cherche Medical
International Classes:
A61K31/165; A61K31/4045; A61K31/5415; A61K31/555; A61K31/7008; A61K49/00; A61K51/00; A61P19/00; C07C231/12; C07C237/20; C07D259/00; C07D279/02; C07D409/06; C07D417/12; C07F13/00; C07H5/06; C07H15/12; (IPC1-7): C07C237/20; A61K31/165; A61K31/4045; A61K31/5415; A61K31/555; A61K31/7008; A61K49/00; A61K51/00; A61P19/00; C07C231/12; C07D259/00; C07D279/02; C07D409/06; C07D417/12; C07H15/12
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)