Title:
The new inhibitor of cyclophilin, and its use
Document Type and Number:
Japanese Patent JP5947724
Kind Code:
B2
Abstract:
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO2, CS, and R1 is in particular H, R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, R6 is in particular H or an alkyl group, and R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
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Inventors:
Giusseau, Jean-Francois
Coriander, lionel
Ahmed-Belkasem, Hakim
Paul Tosky, Jean-Michel
Coriander, lionel
Ahmed-Belkasem, Hakim
Paul Tosky, Jean-Michel
Application Number:
JP2012545292A
Publication Date:
July 06, 2016
Filing Date:
December 21, 2010
Export Citation:
Assignee:
Institut National De La Sante & De La Recherche Medical
DEINOVE
DEINOVE
International Classes:
C07C275/24; A61K31/17; A61K31/223; A61K31/341; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/40; A61K31/4045; A61K31/415; A61K31/4184; A61K31/4196; A61K31/421; A61K31/422; A61K31/4245; A61K31/426; A61K31/433; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4465; A61K31/451; A61K31/454; A61K31/495; A61K31/496; A61K31/505; A61K31/5375; A61K31/5377; A61K31/55; A61K38/00; A61P31/12; C07C275/26; C07C307/06; C07C323/59; C07D207/06; C07D207/08; C07D207/09; C07D209/08; C07D209/26; C07D211/16; C07D211/18; C07D211/26; C07D211/32; C07D211/42; C07D211/46; C07D213/26; C07D213/30; C07D213/73; C07D213/74; C07D223/04; C07D231/04; C07D231/12; C07D235/14; C07D237/04; C07D239/26; C07D239/47; C07D239/92; C07D241/18; C07D249/08; C07D261/08; C07D277/40; C07D285/12; C07D285/135; C07D295/08; C07D295/10; C07D295/12; C07D307/14; C07D307/52; C07D307/81; C07D309/04; C07D317/58; C07D319/18; C07D401/04; C07D401/12; C07D403/06; C07D405/12; C07D413/06; C07D413/12; C07D513/04; C07K5/062
Domestic Patent References:
| JP2005511746A | ||||
| JP9025270A | ||||
| JP2002520372A | ||||
| JP1156966A |
Foreign References:
| WO2007106854A1 | ||||
| WO1991012245A1 | ||||
| WO2007002639A1 | ||||
| CN1590378A |
Other References:
SINGH,J. et al.,Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening,Journal of Medicinal Chemistry,2002年,Vol.45,p.2988-2993
GANTE,J. et al.,Peptide synthesis, I. A new carboxamide synthesis,Chemiker-Zeitung,1985年,Vol.109, No.4,p.155-156
DAVIES,R. et al.,A New General Pathway for Synthesis of Reference Compounds of N-Terminal Valine-Isocyanate Adducts,Chemical Research in Toxicology,2010年,Vol.23,p.540-546
ZVILICHOVSKY,G. et al.,Modified Lossen rearrangement of malonohydroxamic acid. Preparation and properties of 3-(p-tolylsulfonyloxy)hydantoin,The Journal of Organic Chemistry,1969年,Vol.34,p.486-489
WANG,F. et al.,Synthesis and Peptidyl-Prolyl Isomerase Inhibitory Activity of Quinoxalines as Ligands of Cyclophilin A ,Chemical and Pharmaceutical Bulletin,2006年,Vol.54, No.3,p.372-376
GANTE,J. et al.,Peptide synthesis, I. A new carboxamide synthesis,Chemiker-Zeitung,1985年,Vol.109, No.4,p.155-156
DAVIES,R. et al.,A New General Pathway for Synthesis of Reference Compounds of N-Terminal Valine-Isocyanate Adducts,Chemical Research in Toxicology,2010年,Vol.23,p.540-546
ZVILICHOVSKY,G. et al.,Modified Lossen rearrangement of malonohydroxamic acid. Preparation and properties of 3-(p-tolylsulfonyloxy)hydantoin,The Journal of Organic Chemistry,1969年,Vol.34,p.486-489
WANG,F. et al.,Synthesis and Peptidyl-Prolyl Isomerase Inhibitory Activity of Quinoxalines as Ligands of Cyclophilin A ,Chemical and Pharmaceutical Bulletin,2006年,Vol.54, No.3,p.372-376
Attorney, Agent or Firm:
Patent business corporation Tsukuni
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