Title:
タペンタドールおよびその中間体を調製するための新しい方法
Document Type and Number:
Japanese Patent JP5901534
Kind Code:
B2
Abstract:
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below using the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative. The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol.
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Inventors:
Giuseppe Motta
Domenico Bergani
Giorgio Bertolini
Domenico Bergani
Giorgio Bertolini
Application Number:
JP2012541614A
Publication Date:
April 13, 2016
Filing Date:
November 30, 2010
Export Citation:
Assignee:
Uticals Societa Peratini
International Classes:
C07C213/00; C07C215/54; C07C225/08; C07C233/36; C07C245/20
Domestic Patent References:
| JP2009544637A | ||||
| JP2009544658A | ||||
| JP2010508240A | ||||
| JP2006527178A | ||||
| JP8099939A |
Foreign References:
| US3824271 | ||||
| US20080269524 |
Attorney, Agent or Firm:
Patent Business Corporation Tani/Abe Patent Office