Title:
RNAi耐性ウイルス株を克服する新手法
Document Type and Number:
Japanese Patent JP4536112
Kind Code:
B2
Abstract:
A chimeric RNA molecule comprising at least one shRNA (short hairpin RNA) segment capable of forming siRNA which can act through viral RNA (target sequence) to inhibit the replication/growth of a virus or at least one miRNA segment capable of acting through viral RNA (target sequence) to inhibit the expression of a protein involved in the life cycle of the virus, and further comprising at least one RNA segment selected from the group consisting of: at least one decoy RNA segment capable of binding to a protein involved in the life cycle of the virus to inhibit the replication/growth of the virus; at least one antisense RNA segment capable of hybridizing to a gene involved in the life cycle of the virus to inhibit the replication/growth of the virus; an RNA segment comprising at least one ribozyme capable of inhibiting the expression of a protein involved in the life cycle of the virus; an RNA segment comprising at least one tRNase ZL-EGS capable of inhibiting the expression of a protein involved in the life cycle of the virus; and an RNA segment comprising at least one RNase P-EGS capable of inhibiting the expression of a protein involved in the life cycle of the virus, two or more of the RNA segments being cleavably linked to one another.
Inventors:
Takahisa Hiroshi
Naoko Kurosaki
Burner Jacob Samsung
Naoko Kurosaki
Burner Jacob Samsung
Application Number:
JP2007504843A
Publication Date:
September 01, 2010
Filing Date:
February 24, 2006
Export Citation:
Assignee:
Hapro Pharma Co., Ltd.
International Classes:
C12N15/113; A61K31/7105; A61K35/76; A61K48/00; A61P31/14; A61P31/16; A61P31/18; A61P35/00; C12N15/09; C12N15/11; C12N15/51
Domestic Patent References:
| JPH09110894A | 1997-04-28 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka