Title:
新規な方法
Document Type and Number:
Japanese Patent JP5599974
Kind Code:
B2
Abstract:
The present invention relates to processes for the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.
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Inventors:
ヴィナヤク Gee Goa
アヴィナッシュ See guy クワッド
M ガダカー
Buoy Kay Shukla
アヴィナッシュ See guy クワッド
M ガダカー
Buoy Kay Shukla
Application Number:
JP2008536115A
Publication Date:
October 01, 2014
Filing Date:
October 17, 2006
Export Citation:
Assignee:
ジェネリクス [UK] Limited
International Classes:
C07C41/16; C07C43/174; C07C213/00; C07C213/02; C07C217/10; C07C221/00; C07C225/06; A61K31/137; A61P11/08; A61P43/00; C07B51/00; C07B61/00
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Jitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Jitsuhiro